Keratin 13

Keratin 13 (or cytokeratin 13) is a protein that in humans is encoded by the KRT13 gene.[5][6]

KRT13
Identifiers
Aliases	KRT13, CK13, K13, WSN2, keratin 13
External IDs	OMIM: 148065 MGI: 101925 HomoloGene: 40740 GeneCards: KRT13
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,500,981 bp[1] End 41,505,705 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.41 cM Start 100,117,327 bp[2] End 100,121,566 bp[2]
Gene ontology Molecular function • structural molecule activity • GO:0001948 protein binding Cellular component • intermediate filament cytoskeleton • keratin filament • extracellular exosome • intermediate filament • cell nucleus • cytosol Biological process • cellular response to retinoic acid • response to radiation • cytoskeleton organization • tongue morphogenesis • keratinization • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3860	16663
Ensembl	ENSG00000171401	ENSMUSG00000044041
UniProt	P13646	P08730
RefSeq (mRNA)	NM_153490 NM_002274	NM_010662 NM_001313949
RefSeq (protein)	NP_002265 NP_705694	NP_001300878 NP_034792
Location (UCSC)	Chr 17: 41.5 – 41.51 Mb	Chr 11: 100.12 – 100.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Keratin 13 is a type I cytokeratin, it is paired with keratin 4 and found in the suprabasal layers of non-cornified stratified epithelia. Mutations in the gene encoding this protein and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000171401 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044041 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Romano V, Raimondi E, Bosco P, Feo S, Di Pietro C, Leube RE, Troyanovsky SM, Ceratto N (October 1992). "Chromosomal mapping of human cytokeratin 13 gene (KRT13)". Genomics. 14 (2): 495–7. doi:10.1016/S0888-7543(05)80250-2. PMID 1385306.
6. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
7. Richard G, De Laurenzi V, Didona B, Bale SJ, Compton JG (December 1995). "Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus". Nat. Genet. 11 (4): 453–5. doi:10.1038/ng1295-453. PMID 7493031.

Further reading

• Jacques CM, Pereira AL, Maia V, et al. (2009). "Expression of cytokeratins 10, 13, 14 and 19 in oral lichen planus". J Oral Sci. 51 (3): 355–65. doi:10.2334/josnusd.51.355. PMID 19776502.
• Sheng S, Barnett DH, Katzenellenbogen BS (2008). "Differential Estradiol and Selective Estrogen Receptor Modulator (SERM) Regulation of Keratin 13 Gene Expression and its Underlying Mechanism in Breast Cancer Cells". Mol. Cell. Endocrinol. 296 (1–2): 1–9. doi:10.1016/j.mce.2008.09.022. PMC 2654210. PMID 18951949.
• Lu DP, Xing RD, Tatemoto Y, Osaki T (2006). "[Cytokeratin18, 13 and their gene expression in post-operative maxillary cyst linings with metaplastic epithelium]". Zhonghua Kou Qiang Yi Xue Za Zhi. 41 (6): 376–9. PMID 16836912.
• Ceratto N, Dobkin C, Carter M, et al. (1997). "Human type I cytokeratin genes are a compact cluster". Cytogenet. Cell Genet. 77 (3–4): 169–74. doi:10.1159/000134566. PMID 9284906.
• Olson GE, Winfrey VP, Blaeuer GL, et al. (2002). "Stage-specific expression of the intermediate filament protein cytokeratin 13 in luminal epithelial cells of secretory phase human endometrium and peri-implantation stage rabbit endometrium". Biol. Reprod. 66 (4): 1006–15. doi:10.1095/biolreprod66.4.1006. PMID 11906920.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Rugg E, Magee G, Wilson N, et al. (1999). "Identification of two novel mutations in keratin 13 as the cause of white sponge naevus". Oral Dis. 5 (4): 321–4. doi:10.1111/j.1601-0825.1999.tb00097.x. PMID 10561721.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Shibuya Y, Zhang J, Yokoo S, et al. (2003). "Constitutional mutation of keratin 13 gene in familial white sponge nevus". Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 96 (5): 561–5. doi:10.1016/s1079-2104(03)00372-x. PMID 14600690.
• Terrinoni A, Rugg EL, Lane EB, et al. (2001). "A novel mutation in the keratin 13 gene causing oral white sponge nevus". J. Dent. Res. 80 (3): 919–23. doi:10.1177/00220345010800031401. PMID 11379896.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Waseem A, Alam Y, Dogan B, et al. (1998). "Isolation, sequence and expression of the gene encoding human keratin 13". Gene. 215 (2): 269–79. doi:10.1016/S0378-1119(98)00297-2. PMID 9714826.
• Raspollini MR, Fambrini M, Marchionni M, et al. (2007). "In situ adenocarcinoma and squamous carcinoma of uterine cervix. Pathological and immunohistochemical analysis with cytokeratin 13". Eur. J. Obstet. Gynecol. Reprod. Biol. 134 (2): 249–53. doi:10.1016/j.ejogrb.2006.07.047. PMID 16949723.
• Sajjan US, Sylvester FA, Forstner JF (2000). "Cable-Piliated Burkholderia cepacia Binds to Cytokeratin 13 of Epithelial Cells". Infect. Immun. 68 (4): 1787–95. doi:10.1128/IAI.68.4.1787-1795.2000. PMC 97349. PMID 10722565.