RAC3

Ras-related C3 botulinum toxin substrate 3 (Rac3) is a G protein that in humans is encoded by the RAC3 gene.[5] It is an important component of intracellular signalling pathways. Rac3 is a member of the Rac subfamily of the Rho family of small G proteins.[6][7] Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.[5]

RAC3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAC3, ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3), Rac family small GTPase 3
External IDsOMIM: 602050 MGI: 2180784 HomoloGene: 68433 GeneCards: RAC3
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q25.3Start82,031,678 bp[1]
End82,034,204 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5881

170758

Ensembl

ENSG00000169750

ENSMUSG00000018012

UniProt

P60763

P60764

RefSeq (mRNA)

NM_005052
NM_001316307

NM_133223

RefSeq (protein)

NP_001303236
NP_005043

NP_573486

Location (UCSC)Chr 17: 82.03 – 82.03 MbChr 11: 120.72 – 120.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

RAC3 has been shown to interact with CIB1[8] and HNF1A.[9]

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References

  1. GRCh38: Ensembl release 89: ENSG00000169750 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018012 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)".
  6. Courjal F, Chuchana P, Theillet C, Fort P (September 1997). "Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes". Genomics. 44 (2): 242–6. doi:10.1006/geno.1997.4871. PMID 9299243.
  7. Haataja L, Groffen J, Heisterkamp N (August 1997). "Characterization of RAC3, a novel member of the Rho family". J. Biol. Chem. 272 (33): 20384–88. doi:10.1074/jbc.272.33.20384. PMID 9252344.
  8. Haataja, Leena; Kaartinen Vesa; Groffen John; Heisterkamp Nora (March 2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading". J. Biol. Chem. 277 (10): 8321–8. doi:10.1074/jbc.M105363200. ISSN 0021-9258. PMID 11756406. yes
  9. Soutoglou, E; Papafotiou G; Katrakili N; Talianidis I (April 2000). "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". J. Biol. Chem. 275 (17): 12515–20. doi:10.1074/jbc.275.17.12515. ISSN 0021-9258. PMID 10777539. yes

Further reading

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