ATP11B

Probable phospholipid-transporting ATPase IF is an enzyme that in humans is encoded by the ATP11B gene.[5][6][7]

ATP11B
Identifiers
Aliases	ATP11B, ATPIF, ATPIR, ATPase phospholipid transporting 11B (putative)
External IDs	OMIM: 605869 MGI: 1923545 HomoloGene: 32919 GeneCards: ATP11B
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.33 Start 182,793,503 bp[1] End 182,921,629 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 B Start 35,754,106 bp[2] End 35,856,276 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • ion transmembrane transporter activity • metal ion binding • GO:0001948 protein binding • GO:0004012 ATPase-coupled intramembrane lipid transporter activity • hydrolase activity • ATP binding • magnesium ion binding Cellular component • integral component of membrane • recycling endosome • endosome • Golgi apparatus • membrane • cell membrane • nuclear inner membrane • recycling endosome membrane • early endosome • endoplasmic reticulum • azurophil granule membrane • trans-Golgi network Biological process • lipid transport • aminophospholipid transport • phospholipid transport • ion transport • ion transmembrane transport • phospholipid translocation • neutrophil degranulation • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23200	76295
Ensembl	ENSG00000058063	ENSMUSG00000037400
UniProt	Q9Y2G3	n/a
RefSeq (mRNA)	NM_014616	NM_029570
RefSeq (protein)	NP_055431	n/a
Location (UCSC)	Chr 3: 182.79 – 182.92 Mb	Chr 3: 35.75 – 35.86 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000058063 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037400 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
6. Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA (Nov 1999). "Differential expression of putative transbilayer amphipath transporters". Physiological Genomics. 1 (3): 139–50. doi:10.1152/physiolgenomics.1999.1.3.139. PMID 11015572.
7. "Entrez Gene: ATP11B ATPase, Class VI, type 11B".

External links

• Human ATP11B genome location and ATP11B gene details page in the UCSC Genome Browser.

Further reading

• Halleck MS, Schlegel RA, Williamson PL (Mar 2002). "Reanalysis of ATP11B, a type IV P-type ATPase". The Journal of Biological Chemistry. 277 (12): 9736–40. doi:10.1074/jbc.M200240200. PMID 11790799.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.