Dienestrol diacetate

Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol.[1] It is an ester of dienestrol.[1]

Oral potencies of estrogens

Estrogen	Type	Class	ETD (2–3 weeks)	EPD (2–3 weeks)	MSD (2–3 weeks)	MSD (daily)	OID (daily)	TSD (daily)
Estradiol (non-micronized)	Bioidentical	Steroidal	30 mg	≥120–300 mg	120 mg	6 mg	?	?
Estradiol (micronized)	Bioidentical	Steroidal	6–12 mg	60–80 mg	14–42 mg	1–2 mg	>5 mg	>8 mg
Estradiol valerate	Bioidentical	Steroidal	6–12 mg	60–80 mg	14–42 mg	1–2 mg	?	>8 mg
Estradiol benzoate	Bioidentical	Steroidal	?	60–140 mg	?	?	?	?
Estriol	Bioidentical	Steroidal	20 mg^a	120–150 mg^b	28–126 mg	1–6 mg	>5 mg	?
Estriol succinate	Bioidentical	Steroidal	?	140–150 mg^b	28–126 mg	2–6 mg	?	?
Estrone sulfate	Bioidentical	Steroidal	12 mg	60 mg	42 mg	2 mg	?	?
Conjugated estrogens	Natural	Steroidal	5–12 mg	60–80 mg	8.4–25 mg	0.625–1.25 mg	>3.75 mg	7.5 mg
Ethinylestradiol	Synthetic	Steroidal	200 μg	1–2 mg	280 μg	20–40 μg	100 μg	100 μg
Mestranol	Synthetic	Steroidal	300 μg	1.5–3.0 mg	300–600 μg	25–30 μg	>80 μg	?
Quinestrol	Synthetic	Steroidal	300 μg	2–4 mg	500 μg	25–50 μg	?	?
Methylestradiol	Synthetic	Steroidal	?	2 mg	?	?	?	?
Diethylstilbestrol	Synthetic	Nonsteroidal	2.5 mg	20–30 mg	11 mg	0.5–2.0 mg	>5 mg	3 mg
Diethylstilbestrol dipropionate	Synthetic	Nonsteroidal	?	15–30 mg	?	?	?	?
Dienestrol	Synthetic	Nonsteroidal	5 mg	30–40 mg	42 mg	0.5–4.0 mg	?	?
Dienestrol diacetate	Synthetic	Nonsteroidal	3–5 mg	30–60 mg	?	?	?	?
Hexestrol	Synthetic	Nonsteroidal	?	70–110 mg	?	?	?	?
Chlorotrianisene	Synthetic	Nonsteroidal	?	>100 mg	?	?	>48 mg	?
Methallenestril	Synthetic	Nonsteroidal	?	400 mg	?	?	?	?
Footnotes: ^a = Very variable, often higher. ^b = In divided doses, 3x/day; irregular and atypical proliferation. Sources: See template.

Parenteral potencies and durations of nonsteroidal estrogens

Estrogen	Form	Major brand name(s)	EPD (14 days)	Duration
Diethylstilbestrol (DES)	Oil solution	Metestrol	20 mg	1 mg ≈ 2–3 days; 3 mg ≈ 3 days
Diethylstilbestrol dipropionate	Oil solution	Cyren B	12.5–15 mg	2.5 mg ≈ 5 days
	Aqueous suspension	?	5 mg	? mg = 21–28 days
Dimestrol (DES dimethyl ether)	Oil solution	Depot-Cyren, Depot-Oestromon, Retalon Retard	20–40 mg	?
Fosfestrol (DES diphosphate)^a	Aqueous solution	Honvan	?	<1 day
Dienestrol diacetate	Aqueous suspension	Farmacyrol-Kristallsuspension	50 mg	?
Hexestrol dipropionate	Oil solution	Hormoestrol, Retalon Oleosum	25 mg	?
Hexestrol diphosphate^a	Aqueous solution	Cytostesin, Pharmestrin, Retalon Aquosum	?	Very short
Note: All by intramuscular injection unless otherwise noted. Footnotes: ^a = By intravenous injection. Sources: See template.

Dienestrol diacetate

Clinical data
Trade names	Faragynol, Gynocyrol
Drug class	Nonsteroidal estrogen; Estrogen ester
Identifiers
IUPAC name [4-[(2Z,4E)-4-(4-acetyloxyphenyl)hexa-2,4-dien-3-yl]phenyl] acetate
CAS Number	84-19-5
PubChem CID	24884313
ChemSpider	4707742
UNII	D20D148WPQ
ChEMBL	ChEMBL3188355
Chemical and physical data
Formula	C22H22O4
Molar mass	350.414 g·mol^−1
3D model (JSmol)	Interactive image
SMILES C\C=C(c1ccc(OC(C)=O)cc1)/C(=C/C)c2ccc(OC(C)=O)cc2
InChI InChI=1S/C22H22O4/c1-5-21(17-7-11-19(12-8-17)25-15(3)23)22(6-2)18-9-13-20(14-10-18)26-16(4)24/h5-14H,1-4H3/b21-5-,22-6+ Key:YWLLGDVBTLPARJ-LWKKFVLGSA-N

See also

• List of estrogen esters § Esters of other nonsteroidal estrogens
• List of sex-hormonal aqueous suspensions

References

1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 390. ISBN 978-1-4757-2085-3.