Carbestrol

Carbestrol (developmental code names NSC-19962, ORF-2166) is a synthetic, nonsteroidal estrogen of the cyclohexenecarboxylic acid group and seco analogue of doisynolic acid that was described in the literature in 1956 and developed for the treatment of prostate cancer in the 1960s but was never marketed.[1][2][3][4]

Carbestrol

Clinical data
Other names	NSC-19962; ORF-2166
ATC code	None
Identifiers
IUPAC name 3-Ethyl-4-(4-methoxyphenyl)-2-methylcyclohex-3-ene-1-carboxylic acid
CAS Number	1755-52-8
PubChem CID	15644
ChemSpider	14881
UNII	C85AI8SOCH
Chemical and physical data
Formula	C17H22O3
Molar mass	274.360 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CCC1=C(CCC(C1C)C(=O)O)C2=CC=C(C=C2)OC
InChI InChI=1S/C17H22O3/c1-4-14-11(2)15(17(18)19)9-10-16(14)12-5-7-13(20-3)8-6-12/h5-8,11,15H,4,9-10H2,1-3H3,(H,18,19) Key:VJKVHUZOVAWKEB-UHFFFAOYSA-N

See also

• Fenestrel
• Methallenestril
• Doisynoestrol
• Bisdehydrodoisynolic acid

References

1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 516–. ISBN 978-1-4757-2085-3.
2. ARDUINO LJ (1964). "Carbestrol (NSC-19962) Treatment of Patients with Prostatic Carcinoma-Preliminary Report". Cancer Chemother Rep. 39: 67–75. PMID 14201278.
3. Kogler J, Hill G, Sedransk N, Cole DR, Weiss AJ, Wilson W (1972). "Phase II study of carbestrol (NSC-19962) in patients with solid tumors". Cancer Chemother Rep. 56 (5): 641–7. PMID 4652590.
4. Raymond Eller Kirk; Donald Frederick Othmer (1980). Encyclopedia of chemical technology. Wiley. p. 672. ISBN 978-0-471-02065-3.