Methylpiperidinopyrazole

Methylpiperidinopyrazole (MPP) is a synthetic, nonsteroidal, and highly selective antagonist of ERα that is used in scientific research to study the function of this receptor.[1][2][3] It has 200-fold selectivity for ERα over ERβ and 1000-fold selectivity for blocking ERα-mediated gene transcription relative to that of ERβ.[4]

Methylpiperidinopyrazole

Identifiers
IUPAC name 4-[2-(4-hydroxyphenyl)-4-methyl-3-[4-(2-piperidin-1-ylethoxy)phenyl]-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one
CAS Number	289726-02-9
PubChem CID	6604927
ChemSpider	5037183
Chemical and physical data
Formula	C29H31N3O3
Molar mass	469.585 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)OCCN5CCCCC5
InChI InChI=1S/C29H31N3O3/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31/h5-16,30,34H,2-4,17-20H2,1H3 Key:PFTIONINVMINHE-UHFFFAOYSA-N

See also

• Glyceollin
• Propylpyrazoletriol (PPT)
• Diarylpropionitrile (DPN)
• Prinaberel (ERB-041)
• Liquiritigenin
• Menerba
• PHTPP
• (R,R)-Tetrahydrochrysene ((R,R)-THC)

References

1. Tony M. Plant; Anthony J. Zeleznik (15 November 2014). Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Academic Press. pp. 2311–. ISBN 978-0-12-397769-4.
2. Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012. pp. 220–. ISBN 978-1-4649-9741-9.
3. Synthesis of Non-steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (PROTACS). ProQuest. 2008. pp. 11–. ISBN 978-0-549-90990-3.
4. Eckhard Ottow; Hilmar Weinmann (8 September 2008). Nuclear Receptors as Drug Targets. John Wiley & Sons. pp. 50–. ISBN 978-3-527-62330-3.