Fluoroestradiol F-18
Fluoroestradiol F-18, also known as [18F]16α-fluoroestradiol and sold under the brand name Cerianna, is a radioactive diagnostic agent indicated for use with positron emission tomography (PET) imaging.[1][2][3][4][5] It is an analog of estrogen and is used to detect estrogen receptor-positive breast cancer lesions.[1]
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| Trade names | Cerianna |
| Other names | [18F]16α-Fluoroestradiol; [18F]16α-Fluoroestra-1,3,5(10)-triene-3,17β-diol |
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| Routes of administration | Intravenous injection |
| Drug class | Estrogen; Diagnostic radiopharmaceutical |
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| Metabolism | Liver[1] |
| Excretion | Gallbladder and kidney[1] |
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| Formula | C18H23[18F]O2 |
| Molar mass | 289.37[1] |
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Chemistry
Chemically, fluoroestradiol F-18 is [18F]16α-fluoro-3,17β-diol-estratriene-1,3,5(10).[1]
History
Fluoroestradiol F-18 was approved for medical use in the United States in May 2020.[6]
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See also
References
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/212155s000lbl.pdf
- Katzenellenbogen JA (February 2020). "The quest for improving the management of breast cancer by functional imaging: The discovery and development of 16α-[18F]fluoroestradiol (FES), a PET radiotracer for the estrogen receptor, a historical review". Nucl. Med. Biol. doi:10.1016/j.nucmedbio.2020.02.007. PMID 32229068.
- Evangelista L, Guarneri V, Conte PF (2016). "18F-Fluoroestradiol Positron Emission Tomography in Breast Cancer Patients: Systematic Review of the Literature & Meta-Analysis". Curr Radiopharm. 9 (3): 244–257. doi:10.2174/1874471009666161019144950. PMID 27774910.
- Liao GJ, Clark AS, Schubert EK, Mankoff DA (August 2016). "18F-Fluoroestradiol PET: Current Status and Potential Future Clinical Applications". J. Nucl. Med. 57 (8): 1269–75. doi:10.2967/jnumed.116.175596. PMID 27307345.
- Sundararajan L, Linden HM, Link JM, Krohn KA, Mankoff DA (November 2007). "18F-Fluoroestradiol". Semin Nucl Med. 37 (6): 470–6. doi:10.1053/j.semnuclmed.2007.08.003. PMID 17920354.
- "Cerianna: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 22 May 2020.
External links
- "Fluoroestradiol F-18". Drug Information Portal. U.S. National Library of Medicine.
- "Fluoroestradiol F-18". NCI Thesaurus. 4 May 2020.
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