Hexestrol dipropionate

Hexestrol dipropionate (brand name Hexanoestrol, Retalon Oleosum), or hexestrol dipropanoate, is a synthetic, nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol.[1] It is an ester of hexestrol,[1] and has been known since at least 1931.[2] The drug has been used in the past to inhibit lactation in women.[3][4]

Parenteral potencies and durations of nonsteroidal estrogens

Estrogen	Form	Major brand name(s)	EPD (14 days)	Duration
Diethylstilbestrol (DES)	Oil solution	Metestrol	20 mg	1 mg ≈ 2–3 days; 3 mg ≈ 3 days
Diethylstilbestrol dipropionate	Oil solution	Cyren B	12.5–15 mg	2.5 mg ≈ 5 days
	Aqueous suspension	?	5 mg	? mg = 21–28 days
Dimestrol (DES dimethyl ether)	Oil solution	Depot-Cyren, Depot-Oestromon, Retalon Retard	20–40 mg	?
Fosfestrol (DES diphosphate)^a	Aqueous solution	Honvan	?	<1 day
Dienestrol diacetate	Aqueous suspension	Farmacyrol-Kristallsuspension	50 mg	?
Hexestrol dipropionate	Oil solution	Hormoestrol, Retalon Oleosum	25 mg	?
Hexestrol diphosphate^a	Aqueous solution	Cytostesin, Pharmestrin, Retalon Aquosum	?	Very short
Note: All by intramuscular injection unless otherwise noted. Footnotes: ^a = By intravenous injection. Sources: See template.

Hexestrol dipropionate

Clinical data
Other names	Hexestrol 4,4'-dipropionate
Identifiers
IUPAC name [4-[4-(4-propanoyloxyphenyl)hexan-3-yl]phenyl] propanoate
CAS Number	4825-53-0
PubChem CID	107342
ChemSpider	96605
ChEMBL	ChEMBL1577591
Chemical and physical data
Formula	C24H30O4
Molar mass	382.500 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CCC(C1=CC=C(C=C1)OC(=O)CC)C(CC)C2=CC=C(C=C2)OC(=O)CC
InChI InChI=1S/C24H30O4/c1-5-21(17-9-13-19(14-10-17)27-23(25)7-3)22(6-2)18-11-15-20(16-12-18)28-24(26)8-4/h9-16,21-22H,5-8H2,1-4H3 Key:HZLYMVNJKHJFRO-UHFFFAOYSA-N

See also

• Hexestrol diacetate
• Hexestrol dicaprylate
• Hexestrol diphosphate

References

1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 163. doi:10.1007/978-1-4757-2085-3. ISBN 978-1-4757-2085-3. OCLC 898564124.
2. Report. U.S. Government Printing Office. 1931. p. 104. LCCN sn85063598.
3. Quarterly Review of Obstetrics and Gynecology. Washington Institute of Medicine. 1944. p. 714. ISSN 0096-9230. OCLC 1763253.
4. Journal of Clinical Endocrinology. Charles C. Thomas. 1945. p. 194. ISSN 0368-1610. LCCN 45029631. OCLC 1607514.