CKAP5

Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene.[5][6][7] It is the homolog of the Xenopus protein XMAP215[8] and is also known as ch-Tog.

CKAP5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCKAP5, CHTOG, MSPS, TOG, TOGp, ch-TOG, cytoskeleton associated protein 5
External IDsOMIM: 611142 MGI: 1923036 HomoloGene: 8844 GeneCards: CKAP5
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p11.2Start46,743,048 bp[1]
End46,846,308 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9793

75786

Ensembl

ENSG00000175216

ENSMUSG00000040549

UniProt

Q14008

A2AGT5

RefSeq (mRNA)

NM_014756
NM_001008938

NM_001165989
NM_029437

RefSeq (protein)

NP_001008938
NP_055571

NP_001159461
NP_083713

Location (UCSC)Chr 11: 46.74 – 46.85 MbChr 2: 91.53 – 91.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK (KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity.[9]

Interactions

CKAP5 has been shown to interact with TACC1.[10][11]

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References
  1. GRCh38: Ensembl release 89: ENSG00000175216 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040549 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
  6. Charrasse S, Mazel M, Taviaux S, Berta P, Chow T, Larroque C (Feb 1996). "Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors". Eur. J. Biochem. 234 (2): 406–13. doi:10.1111/j.1432-1033.1995.406_b.x. PMID 8536682.
  7. "Entrez Gene: CKAP5 cytoskeleton associated protein 5".
  8. Cassimeris L, Morabito J (2004). "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Mol. Biol. Cell. 15 (4): 1580–90. doi:10.1091/mbc.E03-07-0544. PMC 379257. PMID 14718566.
  9. Barr AR, Gergely F (2008). "MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics". Mol. Cell. Biol. 28 (23): 7199–211. doi:10.1128/MCB.01040-08. PMC 2593372. PMID 18809577.
  10. Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.
  11. Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (Apr 2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC 1222467. PMID 11903063.

Further reading


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