TACC1

Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the TACC1 gene.[4]

TACC1
Identifiers
Aliases	TACC1, Ga55, transforming acidic coiled-coil containing protein 1
External IDs	OMIM: 605301 MGI: 2443510 HomoloGene: 4575 GeneCards: TACC1
Gene location (Mouse) Chr. Chromosome 8 (mouse)[1] Band 8|8 A2 Start 25,154,552 bp[1] End 25,256,588 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • ligand-dependent nuclear receptor binding • estrogen receptor binding • glucocorticoid receptor binding • retinoic acid receptor binding • peroxisome proliferator activated receptor binding • retinoid X receptor binding • thyroid hormone receptor binding Cellular component • midbody • cytoskeleton • membrane • cell nucleus • microtubule organizing center • cytoplasm • microtubule cytoskeleton Biological process • cerebral cortex development • cell division • cell cycle • cellular proliferation • microtubule cytoskeleton organization • GO:0043148 mitotic spindle organization • positive regulation of ligand-dependent nuclear receptor transcription coactivator activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6867	320165
Ensembl	n/a	ENSMUSG00000065954
UniProt	O75410	Q6Y685
RefSeq (mRNA)	NM_001122824 NM_001146216 NM_006283 NM_001330521	NM_177089 NM_199323
RefSeq (protein)	NP_001116296 NP_001139688 NP_001317450 NP_006274 NP_001339707 NP_001339708 NP_001339709 NP_001339710 NP_001339711 NP_001339712 NP_001339713 NP_001339714 NP_001339715 NP_001339716 NP_001339717 NP_001339718 NP_001339719 NP_001339720 NP_001339721 NP_001339722 NP_001339723 NP_001339724 NP_001339725 NP_001339726 NP_001339727 NP_001339728 NP_001339729 NP_001339730 NP_001339731 NP_001339732 NP_001339733	NP_796063 NP_955355
Location (UCSC)	n/a	Chr 8: 25.15 – 25.26 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers.[4]

Interactions

TACC1 has been shown to interact with:

• Aurora A kinase,[5][6]
• Aurora B kinase,[5]
• BARD1,[7]
• CKAP5,[6][8]
• LSM7,[6][9]
• SNRPG,[9] and
• TDRD7.[6]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000065954 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: TACC1 transforming, acidic coiled-coil containing protein 1".
5. Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D (Jun 2004). "Aurora B -TACC1 protein complex in cytokinesis". Oncogene. 23 (26): 4516–22. doi:10.1038/sj.onc.1207593. PMID 15064709.
6. Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.
7. Ryser S, Dizin E, Jefford CE, Delaval B, Gagos S, Christodoulidou A, Krause KH, Birnbaum D, Irminger-Finger I (Feb 2009). "Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2". Cancer Res. 69 (3): 1125–34. doi:10.1158/0008-5472.CAN-08-2134. PMID 19176389.
8. Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (Apr 2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC 1222467. PMID 11903063.
9. Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.

Further reading

• Lappin TR, Mullan RN, Stewart JP, Morgan NA, Thompson A, Maxwell AP (2003). "AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains". Leuk. Lymphoma. 43 (7): 1455–9. doi:10.1080/1042819022386644. PMID 12389629.
• Still IH, Vince P, Cowell JK (1999). "The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines". Genomics. 58 (2): 165–70. doi:10.1006/geno.1999.5829. PMID 10366448.
• Still IH, Hamilton M, Vince P, Wolfman A, Cowell JK (1999). "Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon". Oncogene. 18 (27): 4032–8. doi:10.1038/sj.onc.1202801. PMID 10435627.
• Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Gergely F, Karlsson C, Still I, Cowell J, Kilmartin J, Raff JW (2001). "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14352–7. doi:10.1073/pnas.97.26.14352. PMC 18922. PMID 11121038.
• Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC 1222467. PMID 11903063.
• Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC (2002). "Serological identification and expression analysis of gastric cancer-associated genes". Br. J. Cancer. 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473.
• Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.
• Line A, Slucka Z, Stengrevics A, Li G, Rees RC (2003). "Altered splicing pattern of TACC1 mRNA in gastric cancer". Cancer Genet. Cytogenet. 139 (1): 78–83. doi:10.1016/S0165-4608(02)00607-6. PMID 12547166.
• Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.
• Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH (2004). "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases". Oncogene. 23 (14): 2559–63. doi:10.1038/sj.onc.1207424. PMID 14767476.
• Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D (2004). "Aurora B -TACC1 protein complex in cytokinesis". Oncogene. 23 (26): 4516–22. doi:10.1038/sj.onc.1207593. PMID 15064709.
• Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P (2004). "Structure-function evolution of the Transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms". BMC Evol. Biol. 4: 16. doi:10.1186/1471-2148-4-16. PMC 441373. PMID 15207008.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Lauffart B, Dimatteo A, Vaughan MM, Cincotta MA, Black JD, Still IH (2007). "Temporal and spatial expression of TACC1 in the mouse and human". Dev. Dyn. 235 (6): 1638–47. doi:10.1002/dvdy.20724. PMID 16496324.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.