CEP152

Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene.[5] It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.[6]

CEP152
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N7V
Identifiers
Aliases	CEP152, MCPH4, MCPH9, SCKL5, centrosomal protein 152
External IDs	OMIM: 613529 MGI: 2139083 HomoloGene: 37159 GeneCards: CEP152
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.1 Start 48,712,928 bp[1] End 48,811,146 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 125,563,088 bp[2] End 125,625,113 bp[2]
Gene ontology Molecular function • protein kinase binding • GO:0001948 protein binding Cellular component • deuterosome • cytosol • centriole • nucleoplasm • cytoplasm • pericentriolar material • microtubule organizing center • cytoskeleton • centrosome Biological process • cell projection organization • G2/M transition of mitotic cell cycle • de novo centriole assembly involved in multi-ciliated epithelial cell differentiation • centrosome duplication • centriole replication • ciliary basal body docking • regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22995	99100
Ensembl	ENSG00000103995	ENSMUSG00000068394
UniProt	O94986	A2AUM9
RefSeq (mRNA)	NM_001194998 NM_014985	NM_001081091
RefSeq (protein)	NP_001181927 NP_055800	NP_001074560
Location (UCSC)	Chr 15: 48.71 – 48.81 Mb	Chr 2: 125.56 – 125.63 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000103995 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068394 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: centrosomal protein 152kDa".
6. Blachon S, Gopalakrishnan J, Omori Y, Polyanovsky A, Church A, Nicastro D, Malicki J, Avidor-Reiss T (December 2008). "Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication". Genetics. 180 (4): 2081–94. doi:10.1534/genetics.108.095141. PMC 2600943. PMID 18854586.

External links

• Human CEP152 genome location and CEP152 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: O94986 (Centrosomal protein of 152 kDa) at the PDBe-KB.

Further reading

• Nakayama M, Kikuno R, Ohara O (2002). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Nagase T, Ishikawa K, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
• Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". J. Cell Biol. 129 (6): 1617–28. doi:10.1083/jcb.129.6.1617. PMC 2291169. PMID 7790358.
• Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell. 5 (1): 113–25. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mayor T, Stierhof YD, Tanaka K, et al. (2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837–46. doi:10.1083/jcb.151.4.837. PMC 2169446. PMID 11076968.
• Petretti C, Savoian M, Montembault E, et al. (2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation". EMBO Rep. 7 (4): 418–24. doi:10.1038/sj.embor.7400639. PMC 1456919. PMID 16462731.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takahashi M, Yamagiwa A, Nishimura T, et al. (2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.