CNTROB

Centrobin is a protein that in humans is encoded by the CNTROB gene.[5] It is a centriole-associated protein that asymmetrically localizes to the daughter centriole, and is required for centriole duplication and cytokinesis.[6]

CNTROB
Identifiers
Aliases	CNTROB, LIP8, PP1221, centrobin, centriole duplication and spindle assembly protein
External IDs	OMIM: 611425 MGI: 2443290 HomoloGene: 14205 GeneCards: CNTROB
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,932,101 bp[1] End 7,949,920 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 69,299,487 bp[2] End 69,323,775 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • protein domain specific binding Cellular component • centriole • centrosome • cytoskeleton • cytoplasm • cytosol Biological process • cell cycle • mitotic cytokinetic process • centrosome separation • cell division • centriole replication • regulation of cilium assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116840	216846
Ensembl	ENSG00000170037	ENSMUSG00000032782
UniProt	Q8N137	Q8CB62
RefSeq (mRNA)	NM_001037144 NM_053051 NM_001330124 NM_001353202 NM_001353203 NM_001353204 NM_001353205 NM_001353206 NM_001353207 NM_001353208 NM_001353209	NM_172560
RefSeq (protein)	NP_001032221 NP_001317053 NP_444279 NP_001340131 NP_001340132 NP_001340133 NP_001340134 NP_001340135 NP_001340136 NP_001340137 NP_001340138	NP_766148
Location (UCSC)	Chr 17: 7.93 – 7.95 Mb	Chr 11: 69.3 – 69.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000170037 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032782 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tchernev, V. T.; Mansfield, T. A.; Giot, L.; Kumar, A. M.; Nandabalan, K.; Li, Y.; Mishra, V. S.; Detter, J. C.; Rothberg, J. M.; Wallace, M. R.; Southwick, F. S.; Kingsmore, S. F. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular medicine (Cambridge, Massachusetts). 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
6. Zou, C.; Li, J.; Bai, Y.; Gunning, W.; Wazer, D.; Band, V.; Gao, Q. (2005). "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication". Journal of Cell Biology. 171 (3): 437–445. doi:10.1083/jcb.200506185. PMC 2171251. PMID 16275750.

External links

• Human CNTROB genome location and CNTROB gene details page in the UCSC Genome Browser.

Further reading

• Jeong Y, Lee J, Kim K, et al. (2007). "Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization". J. Cell Sci. 120 (Pt 12): 2106–16. doi:10.1242/jcs.03458. PMID 17535851.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.