CNTRL

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.[5][6]

For the Electronic Dance Music educational initiative, see CNTRL: Beyond EDM.

CNTRL
Identifiers
Aliases	CNTRL, CEP1, CEP110, FAN, bA165P4.1, centriolin
External IDs	OMIM: 605496 MGI: 1889576 HomoloGene: 38260 GeneCards: CNTRL
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.2 Start 121,074,863 bp[1] End 121,177,610 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 35,109,492 bp[2] End 35,178,822 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein tyrosine kinase activity • cytoskeletal protein binding Cellular component • microtubule organizing center • centrosome • cytoskeleton • membrane • cytoplasm • cytosol • midbody • Flemming body • centriolar subdistal appendage Biological process • cell division • cell cycle • G2/M transition of mitotic cell cycle • peptidyl-tyrosine phosphorylation • GO:0007067 mitotic cell cycle • ciliary basal body docking • regulation of G2/M transition of mitotic cell cycle • regulation of cytoskeleton organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11064	26920
Ensembl	ENSG00000119397	ENSMUSG00000057110
UniProt	Q7Z7A1	A2AL36
RefSeq (mRNA)	NM_007018 NM_001330762 NM_001369892 NM_001369893 NM_001369894 NM_001369895 NM_001369896	NM_001290635 NM_012018 NM_030000 NM_001379274 NM_001379275
RefSeq (protein)	NP_001317691 NP_008949 NP_001356821 NP_001356822 NP_001356823 NP_001356824 NP_001356825	NP_001277564 NP_036148 NP_001366203 NP_001366204
Location (UCSC)	Chr 9: 121.07 – 121.18 Mb	Chr 2: 35.11 – 35.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000119397 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057110 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ (Mar 2000). "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)". Blood. 95 (5): 1788–96. PMID 10688839.
6. "Entrez Gene: CEP110 centrosomal protein 110kDa".

External links

• Human CNTRL genome location and CNTRL gene details page in the UCSC Genome Browser.

Further reading

• Gromley A, Yeaman C, Rosa J, et al. (2005). "Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission". Cell. 123 (1): 75–87. doi:10.1016/j.cell.2005.07.027. PMID 16213214.
• Guinn BA, Bland EA, Lodi U, et al. (2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochem. Biophys. Res. Commun. 335 (4): 1293–304. doi:10.1016/j.bbrc.2005.08.024. PMID 16112646.
• Jurczyk A, Gromley A, Redick S, et al. (2004). "Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly". J. Cell Biol. 166 (5): 637–43. doi:10.1083/jcb.200405023. PMC 2172416. PMID 15337773.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gromley A, Jurczyk A, Sillibourne J, et al. (2003). "A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase". J. Cell Biol. 161 (3): 535–45. doi:10.1083/jcb.200301105. PMC 2172935. PMID 12732615.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ou YY, Mack GJ, Zhang M, Rattner JB (2002). "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation". J. Cell Sci. 115 (Pt 9): 1825–35. PMID 11956314.
• Popovici C, Mattéi MG, Rattner JB, et al. (2000). "Assignment of the centrosomal protein 110 gene (Cep110) to mouse chromosome bands 2B-C1 by in situ hybridization". Cytogenet. Cell Genet. 89 (3–4): 216–7. doi:10.1159/000015616. PMID 10965126.
• Osaki E, Nishina Y, Inazawa J, et al. (1999). "Identification of a novel Sry-related gene and its germ cell-specific expression". Nucleic Acids Res. 27 (12): 2503–10. doi:10.1093/nar/27.12.2503. PMC 148454. PMID 10359848.
• Schütze S, Machleidt T, Adam D, et al. (1999). "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling". J. Biol. Chem. 274 (15): 10203–12. doi:10.1074/jbc.274.15.10203. PMID 10187805.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.