CEP164

Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene.[5][6] Its function appears two be twofold: CEP164 is required for primary cilium formation.[7] Furthermore, it is an important component in the response to DNA damage by UV light.[8][9]

CEP164
Identifiers
AliasesCEP164, NPHP15, centrosomal protein 164
External IDsOMIM: 614848 MGI: 2384878 HomoloGene: 51110 GeneCards: CEP164
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q23.3Start117,314,557 bp[1]
End117,413,266 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

22897

214552

Ensembl

ENSG00000110274

ENSMUSG00000043987

UniProt

Q9UPV0

Q5DU05

RefSeq (mRNA)

NM_001271933
NM_014956

NM_001081373

RefSeq (protein)

NP_001258862
NP_055771

n/a

Location (UCSC)Chr 11: 117.31 – 117.41 MbChr 9: 45.77 – 45.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000110274 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000043987 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: centrosomal protein 164kDa".
  6. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
  7. Graser, S.; Stierhof, Y. -D.; Lavoie, S. B.; Gassner, O. S.; Lamla, S.; Le Clech, M.; Nigg, E. A. (2007). "Cep164, a novel centriole appendage protein required for primary cilium formation". The Journal of Cell Biology. 179 (2): 321–30. doi:10.1083/jcb.200707181. PMC 2064767. PMID 17954613.
  8. Sivasubramaniam, S.; Sun, X.; Pan, Y. -R.; Wang, S.; Lee, E. Y. -H. P. (2008). "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1". Genes & Development. 22 (5): 587–600. doi:10.1101/gad.1627708. PMC 2259029. PMID 18283122.
  9. Pan, YR; Lee, EY (2009). "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity". Cell Cycle. 8 (4): 655–64. doi:10.4161/cc.8.4.7844. PMID 19197159.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.