CEP97

Centrosomal protein of 97 kDa (Cep97), also known as leucine-rich repeat and IQ domain-containing protein 2 (LRRIQ2), is a protein that in humans is encoded by the CEP97 gene.[5]

CEP97
Identifiers
Aliases	CEP97, 2810403B08Rik, LRRIQ2, centrosomal protein 97
External IDs	OMIM: 615864 MGI: 1921451 HomoloGene: 11579 GeneCards: CEP97
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q12.3 Start 101,724,593 bp[1] End 101,770,562 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C1.1 Start 55,899,888 bp[2] End 55,934,855 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • calmodulin binding Cellular component • centrosome • cytoskeleton • microtubule organizing center • cytoplasm • cytosol • macromolecular complex Biological process • cell projection organization • negative regulation of cilium assembly • regulation of mitotic spindle assembly • ciliary basal body docking Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79598	74201
Ensembl	ENSG00000182504	ENSMUSG00000022604
UniProt	Q8IW35	Q9CZ62
RefSeq (mRNA)	NM_001303401 NM_024548	NM_001159364 NM_001159365 NM_001159366 NM_028815
RefSeq (protein)	NP_001290330 NP_078824	NP_001152836 NP_001152837 NP_001152838 NP_083091
Location (UCSC)	Chr 3: 101.72 – 101.77 Mb	Chr 16: 55.9 – 55.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Cep97 along with CP110 inhibit generation of cilia.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000182504 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022604 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: centrosomal protein 97kDa".
6. Spektor A, Tsang WY, Khoo D, Dynlacht BD (August 2007). "Cep97 and CP110 suppress a cilia assembly program". Cell. 130 (4): 678–690. doi:10.1016/j.cell.2007.06.027. PMID 17719545.

External links

• Human CEP97 genome location and CEP97 gene details page in the UCSC Genome Browser.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Svendsen JM, Smogorzewska A, Sowa ME, et al. (2009). "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair". Cell. 138 (1): 63–77. doi:10.1016/j.cell.2009.06.030. PMC 2720686. PMID 19596235.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bettencourt-Dias M, Carvalho-Santos Z (2008). "Double life of centrioles: CP110 in the spotlight". Trends Cell Biol. 18 (1): 8–11. doi:10.1016/j.tcb.2007.11.002. PMID 18068367.
• Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
• Tsang WY, Spektor A, Vijayakumar S, et al. (2009). "Cep76, a centrosomal protein that specifically restrains centriole reduplication". Dev. Cell. 16 (5): 649–660. doi:10.1016/j.devcel.2009.03.004. PMC 4062978. PMID 19460342.