Centrin 1

Centrin-1 is a protein that in humans is encoded by the CETN1 gene.[5][6] It belongs to the centrin family of proteins.

CETN1
Identifiers
Aliases	CETN1, CEN1, CETN, centrin 1
External IDs	OMIM: 603187 MGI: 1347086 HomoloGene: 105668 GeneCards: CETN1
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.32 Start 580,380 bp[1] End 582,114 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 9,615,524 bp[2] End 9,619,478 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • microtubule binding • calcium ion binding • G-protein beta/gamma-subunit complex binding • heterotrimeric G-protein binding • GO:0001948 protein binding • metal ion binding Cellular component • cytoplasm • microtubule organizing center • centrosome • spindle pole • cytoskeleton • photoreceptor connecting cilium • centriole • cell nucleus Biological process • cell cycle • cellular response to heat • cell division • mitotic cytokinesis • centriole replication • regulation of centrosome duplication • calcium-mediated signaling • regulation of cytokinesis • microtubule cytoskeleton organization • nucleotide-excision repair • GO:0007067 mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1068	26369
Ensembl	ENSG00000177143	ENSMUSG00000050996
UniProt	Q12798	P41209
RefSeq (mRNA)	NM_004066	NM_007593
RefSeq (protein)	NP_004057	NP_031619
Location (UCSC)	Chr 18: 0.58 – 0.58 Mb	Chr 18: 9.62 – 9.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000177143 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050996 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Errabolu R, Sanders MA, Salisbury JL (Jun 1994). "Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles". J Cell Sci. 107. ( Pt 1): 9–16. PMID 8175926.
6. "Entrez Gene: CETN1 centrin, EF-hand protein, 1".

External links

• Human CETN1 genome location and CETN1 gene details page in the UCSC Genome Browser.

Further reading

• Tsang WY, Spektor A, Luciano DJ, et al. (2006). "CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability". Mol. Biol. Cell. 17 (8): 3423–34. doi:10.1091/mbc.E06-04-0371. PMC 1525247. PMID 16760425.
• Zhao ZS, Lim JP, Ng YW, et al. (2006). "The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A". Mol. Cell. 20 (2): 237–49. doi:10.1016/j.molcel.2005.08.035. PMID 16246726.
• Poole E, Strappe P, Mok HP, et al. (2005). "HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET". Traffic. 6 (9): 741–55. doi:10.1111/j.1600-0854.2005.00312.x. PMID 16101678.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lutz W, Lingle WL, McCormick D, et al. (2001). "Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication". J. Biol. Chem. 276 (23): 20774–80. doi:10.1074/jbc.M101324200. PMID 11279195.
• Laoukili J, Perret E, Middendorp S, et al. (2000). "Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro". J. Cell Sci. 113. ( Pt 8): 1355–64. PMID 10725219.