CEP68

Centrosomal protein of 68 kDa is a protein that in humans is encoded by the CEP68 gene.[5][6][7][8] CEP68 is required for centrosome cohesion. It decorates fibres emanating from the proximal ends of centrioles. During mitosis, CEP68 dissociates from centrosomes. CEP68 and rootletin depend both on each other for centriole association, and both also require CEP250 for their function.[9]

CEP68
Identifiers
Aliases	CEP68, KIAA0582, centrosomal protein 68
External IDs	OMIM: 616889 MGI: 2667663 HomoloGene: 65235 GeneCards: CEP68
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p14 Start 65,056,366 bp[1] End 65,087,004 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A3.1|11 12.92 cM Start 20,227,037 bp[2] End 20,249,429 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein domain specific binding • protein kinase binding • GO:0001948 protein binding Cellular component • cell junction • cell nucleus • centrosome • microtubule organizing center • cytoskeleton • cytoplasm • cytosol Biological process • protein localization to organelle • centriole-centriole cohesion • centrosome cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23177	216543
Ensembl	ENSG00000011523	ENSMUSG00000044066
UniProt	Q76N32	Q8C0D9
RefSeq (mRNA)	NM_015147 NM_001319100 NM_001319101	NM_172260
RefSeq (protein)	NP_001306029 NP_001306030 NP_055962	NP_758464
Location (UCSC)	Chr 2: 65.06 – 65.09 Mb	Chr 11: 20.23 – 20.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000011523 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044066 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
6. "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. Nov 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
7. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
8. "Entrez Gene: CEP68 centrosomal protein 68kDa".
9. Graser S, Stierhof YD, Nigg EA (Dec 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion". Journal of Cell Science. 120 (Pt 24): 4321–31. doi:10.1242/jcs.020248. PMID 18042621.

External links

• Human CEP68 genome location and CEP68 gene details page in the UCSC Genome Browser.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
• Wang HY, Chien HC, Osada N, Hashimoto K, Sugano S, Gojobori T, Chou CK, Tsai SF, Wu CI, Shen CK (Feb 2007). "Rate of evolution in brain-expressed genes in humans and other primates". PLoS Biology. 5 (2): e13. doi:10.1371/journal.pbio.0050013. PMC 1717015. PMID 17194215.
• Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP (Jul 2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells". Proteomics. 7 (14): 2384–97. doi:10.1002/pmic.200600968. PMID 17570516.