CEP57

Centrosomal protein of 57 kDa is a protein that in humans is encoded by the CEP57 gene.[5][6]

CEP57
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4L0R
Identifiers
Aliases	CEP57, MVA2, PIG8, TSP57, centrosomal protein 57
External IDs	OMIM: 607951 MGI: 1915551 HomoloGene: 8790 GeneCards: CEP57
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q21 Start 95,789,965 bp[1] End 95,832,693 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A1 Start 13,807,792 bp[2] End 13,827,107 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • microtubule binding • GO:0001948 protein binding • identical protein binding • fibroblast growth factor binding • gamma-tubulin binding Cellular component • cytosol • centrosome • Golgi apparatus • microtubule organizing center • microtubule • cytoskeleton • cell nucleus • cytoplasm • microtubule cytoskeleton • nucleoplasm Biological process • fibroblast growth factor receptor signaling pathway • microtubule anchoring • G2/M transition of mitotic cell cycle • spermatid development • mitotic sister chromatid segregation • protein homooligomerization • ciliary basal body docking • regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9702	74360
Ensembl	ENSG00000166037	ENSMUSG00000031922
UniProt	Q86XR8	Q8CEE0
RefSeq (mRNA)	NM_001243776 NM_001243777 NM_014679 NM_001363604	NM_026665 NM_001310721
RefSeq (protein)	NP_001230705 NP_001230706 NP_055494 NP_001350533	NP_001297650 NP_080941
Location (UCSC)	Chr 11: 95.79 – 95.83 Mb	Chr 9: 13.81 – 13.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Translokin binds basic fibroblast growth factor (FGF2; MIM 134920) and mediates its nuclear translocation and mitogenic activity (Bossard et al., 2003).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000166037 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031922 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
6. "Entrez Gene: CEP57 centrosomal protein 57kDa".

External links

• Human CEP57 genome location and CEP57 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 57 kDa

Further reading

• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bossard C, Laurell H, Van den Berghe L, et al. (2003). "Translokin is an intracellular mediator of FGF-2 trafficking". Nat. Cell Biol. 5 (5): 433–9. doi:10.1038/ncb979. PMID 12717444.
• Kim YS, Nakanishi G, Oudes AJ, et al. (2004). "Tsp57: a novel gene induced during a specific stage of spermatogenesis". Biol. Reprod. 70 (1): 106–13. doi:10.1095/biolreprod.103.018465. PMID 12954732.
• Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus". J. Biochem. Mol. Biol. 37 (6): 741–8. doi:10.5483/bmbrep.2004.37.6.741. PMID 15607035.