CEP135

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene.[5][6][7] It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material.[8] CEP135 is required for the centriolar localization of CEP250.[9]

CEP135
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCEP135, CEP4, KIAA0635, MCPH8, centrosomal protein 135
External IDsOMIM: 611423 MGI: 2681869 HomoloGene: 45709 GeneCards: CEP135
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q12Start55,948,871 bp[1]
End56,033,361 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9662

381644

Ensembl

ENSG00000174799

ENSMUSG00000036403

UniProt

Q66GS9

Q6P5D4

RefSeq (mRNA)

NM_014645
NM_025009

NM_199032

RefSeq (protein)

NP_079285

NP_950197

Location (UCSC)Chr 4: 55.95 – 56.03 MbChr 5: 76.59 – 76.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000174799 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036403 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
  7. "Entrez Gene: CEP135 centrosomal protein 135kDa".
  8. Ohta T, Essner R, Ryu JH, Palazzo RE, Uetake Y, Kuriyama R (January 2002). "Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells". J. Cell Biol. 156 (1): 87–99. doi:10.1083/jcb.200108088. PMC 2173569. PMID 11781336.
  9. Kim K, Lee S, Chang J, Rhee K (December 2008). "A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization". Exp. Cell Res. 314 (20): 3692–700. doi:10.1016/j.yexcr.2008.09.016. PMID 18851962.
  • Human CEP135 genome location and CEP135 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 135 kDa

Further reading


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