CEP55

Centrosomal protein of 55 kDa is a protein that in humans is encoded by the CEP55 gene.[5][6]

CEP55
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E1R, 3WUT, 3WUU, 3WUV
Identifiers
Aliases	CEP55, C10orf3, CT111, URCC6, centrosomal protein 55, MARCH
External IDs	OMIM: 610000 MGI: 1921357 HomoloGene: 10019 GeneCards: CEP55
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.33 Start 93,496,612 bp[1] End 93,529,092 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C2 Start 38,055,011 bp[2] End 38,074,423 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • centriole • centrosome • cleavage furrow • cytoskeleton • membrane • intercellular bridge • midbody • microtubule organizing center • cell membrane • Flemming body Biological process • cell division • cell cycle • cell separation after cytokinesis • mitotic cytokinesis • mitotic metaphase plate congression • nucleus organization • establishment of protein localization • renal system development • cranial skeletal system development • multicellular organism development • regulation of phosphatidylinositol 3-kinase signaling • midbody abscission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55165	74107
Ensembl	ENSG00000138180	ENSMUSG00000024989
UniProt	Q53EZ4	Q8BT07
RefSeq (mRNA)	NM_001127182 NM_018131	NM_001164362 NM_028293 NM_028760 NM_001360663
RefSeq (protein)	NP_001120654 NP_060601	NP_001157834 NP_082569 NP_083036 NP_001347592
Location (UCSC)	Chr 10: 93.5 – 93.53 Mb	Chr 19: 38.06 – 38.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

CEP55 is a mitotic phosphoprotein that plays a key role in cytokinesis, the final stage of cell division.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000138180 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024989 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fabbro M, Zhou BB, Takahashi M, Sarcevic B, Lal P, Graham ME, Gabrielli BG, Robinson PJ, Nigg EA, Ono Y, Khanna KK (Oct 2005). "Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis". Dev Cell. 9 (4): 477–88. doi:10.1016/j.devcel.2005.09.003. PMID 16198290.
6. "Entrez Gene: CEP55 centrosomal protein 55kDa".
7. van der Horst A, Simmons J, Khanna KK (November 2009). "Cep55 stabilization is required for normal execution of cytokinesis". Cell Cycle. 8 (22): 3742–9. doi:10.4161/cc.8.22.10047. PMID 19855176.

External links

• Human CEP55 genome location and CEP55 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Martinez-Garay I, Rustom A, Gerdes HH, Kutsche K (2006). "The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody". Genomics. 87 (2): 243–53. doi:10.1016/j.ygeno.2005.11.006. PMID 16406728.
• Zhao WM, Seki A, Fang G (2006). "Cep55, a Microtubule-bundling Protein, Associates with Centralspindlin to Control the Midbody Integrity and Cell Abscission during Cytokinesis". Mol. Biol. Cell. 17 (9): 3881–96. doi:10.1091/mbc.E06-01-0015. PMC 1593165. PMID 16790497.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Chen CH, Lu PJ, Chen YC, et al. (2007). "FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway". Oncogene. 26 (29): 4272–83. doi:10.1038/sj.onc.1210207. PMID 17237822.
• Carlton JG, Martin-Serrano J (2007). "Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery". Science. 316 (5833): 1908–12. doi:10.1126/science.1143422. PMID 17556548.
• Morita E, Sandrin V, Chung HY, et al. (2007). "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis". EMBO J. 26 (19): 4215–27. doi:10.1038/sj.emboj.7601850. PMC 2230844. PMID 17853893.