CEP70

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene.[5][6] The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.[7]

CEP70
Identifiers
Aliases	CEP70, BITE, centrosomal protein 70
External IDs	OMIM: 614310 MGI: 1915371 HomoloGene: 11387 GeneCards: CEP70
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.3 Start 138,494,344 bp[1] End 138,594,538 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 99,243,367 bp[2] End 99,300,404 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • identical protein binding • gamma-tubulin binding Cellular component • microtubule organizing center • cytoskeleton • cytoplasm • nucleoplasm • cytosol • nuclear membrane • centrosome Biological process • G2/M transition of mitotic cell cycle • ciliary basal body docking • regulation of G2/M transition of mitotic cell cycle • cilium morphogenesis • regulation of microtubule cytoskeleton organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80321	68121
Ensembl	ENSG00000114107	ENSMUSG00000056267
UniProt	Q8NHQ1	Q6IQY5
RefSeq (mRNA)	NM_001288964 NM_001288965 NM_001288966 NM_001288967 NM_024491 NM_001320598 NM_001320599 NM_001320600	NM_023873
RefSeq (protein)	NP_001275893 NP_001275894 NP_001275895 NP_001275896 NP_001307527 NP_001307528 NP_001307529 NP_077817	NP_076362
Location (UCSC)	Chr 3: 138.49 – 138.59 Mb	Chr 9: 99.24 – 99.3 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000114107 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056267 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
6. "Entrez Gene: CEP70 centrosomal protein 70kDa".
7. Shi X, Sun X, Liu M, Li D, Aneja R, Zhou J (September 2011). "CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly". J. Biol. Chem. 286 (38): 33401–8. doi:10.1074/jbc.M111.252262. PMC 3190865. PMID 21795687.

External links

• Human CEP70 genome location and CEP70 gene details page in the UCSC Genome Browser.

Further reading

• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.