COPZ1

Coatomer subunit zeta-1 is a protein that in humans is encoded by the COPZ1 gene.[5]

COPZ1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HF6, 5A1U, 5A1V, 5A1W, 5A1X, 5A1Y
Identifiers
Aliases	COPZ1, COPZ, HSPC181, zeta-COP, zeta1-COP, CGI-120, coatomer protein complex subunit zeta 1, COPI coat complex subunit zeta 1
External IDs	OMIM: 615472 MGI: 1929063 HomoloGene: 9366 GeneCards: COPZ1
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 54,301,202 bp[1] End 54,351,846 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 58.74 cM Start 103,272,714 bp[2] End 103,299,868 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22818	56447
Ensembl	ENSG00000111481	ENSMUSG00000060992
UniProt	P61923	P61924
RefSeq (mRNA)	NM_001271734 NM_001271735 NM_001271736 NM_016057	NM_019817 NM_001357748
RefSeq (protein)	NP_001258663 NP_001258664 NP_001258665 NP_057141	NP_062791 NP_001344677
Location (UCSC)	Chr 12: 54.3 – 54.35 Mb	Chr 15: 103.27 – 103.3 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

COPZ1 has been shown to interact with COPG.[6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000111481 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060992 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: COPZ1 coatomer protein complex, subunit zeta 1".
6. Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (November 2000). "Identification and characterization of novel isoforms of COP I subunits". J. Biochem. 128 (5): 793–801. doi:10.1093/oxfordjournals.jbchem.a022817. PMID 11056392.
7. Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H (Oct 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex" (PDF). J. Cell Biol. 135 (1): 53–61. doi:10.1083/jcb.135.1.53. PMC 2121028. PMID 8858162.

External links

• Human COPZ1 genome location and COPZ1 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P61923 (Human Coatomer subunit zeta-1) at the PDBe-KB.

Further reading

• Pelham HR, Rothman JE (2000). "The debate about transport in the Golgi--two sides of the same coin?". Cell. 102 (6): 713–9. doi:10.1016/S0092-8674(00)00060-X. PMID 11030615.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. doi:10.1073/pnas.95.5.2140. PMC 19276. PMID 9482852.
• Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (2001). "Identification and characterization of novel isoforms of COP I subunits". J. Biochem. 128 (5): 793–801. doi:10.1093/oxfordjournals.jbchem.a022817. PMID 11056392.