AP3S1

AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene.[5][6][7]

AP3S1
Identifiers
Aliases	AP3S1, CLAPS3, Sigma3A, adaptor related protein complex 3 sigma 1 subunit, adaptor related protein complex 3 subunit sigma 1
External IDs	OMIM: 601507 MGI: 1337062 HomoloGene: 4254 GeneCards: AP3S1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q22.3-q23.1 Start 115,841,481 bp[1] End 115,914,081 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 C Start 46,741,876 bp[2] End 46,790,826 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • transporter activity Cellular component • AP-3 adaptor complex • membrane coat • Golgi apparatus • AP-type membrane coat adaptor complex • transport vesicle • cytoplasmic vesicle membrane • intracellular membrane-bounded organelle • membrane • cytoplasmic vesicle • axon cytoplasm Biological process • anterograde axonal transport • protein transport • insulin receptor signaling pathway • anterograde synaptic vesicle transport • intracellular protein transport • vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1176	11777
Ensembl	ENSG00000177879	ENSMUSG00000024480
UniProt	Q92572	Q9DCR2
RefSeq (mRNA)	NM_001002924 NM_001284 NM_001318090 NM_001318091 NM_001318093 NM_001318094	NM_009681 NM_001303015
RefSeq (protein)	NP_001002924 NP_001275 NP_001305019 NP_001305020 NP_001305022 NP_001305023 NP_001351048 NP_001351049 NP_001351051	NP_001289944 NP_033811
Location (UCSC)	Chr 5: 115.84 – 115.91 Mb	Chr 18: 46.74 – 46.79 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000177879 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024480 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Watanabe TK, Shimizu F, Nagata M, Takaichi A, Fujiwara T, Nakamura Y, Takahashi E, Hirai Y (Sep 1996). "Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain". Cytogenetics and Cell Genetics. 73 (3): 214–7. doi:10.1159/000134341. PMID 8697810.
6. Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (March 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". The EMBO Journal. 16 (5): 917–28. doi:10.1093/emboj/16.5.917. PMC 1169692. PMID 9118953.
7. "Entrez Gene: AP3S1 adaptor-related protein complex 3, sigma 1 subunit".

External links

• Human AP3S1 genome location and AP3S1 gene details page in the UCSC Genome Browser.

Further reading

• Simpson F, Peden AA, Christopoulou L, Robinson MS (May 1997). "Characterization of the adaptor-related protein complex, AP-3". The Journal of Cell Biology. 137 (4): 835–45. doi:10.1083/jcb.137.4.835. PMC 2139840. PMID 9151686.
• VanRenterghem B, Morin M, Czech MP, Heller-Harrison RA (November 1998). "Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes". The Journal of Biological Chemistry. 273 (45): 29942–9. doi:10.1074/jbc.273.45.29942. PMID 9792713.
• Rodionov DG, Höning S, Silye A, Kongsvik TL, von Figura K, Bakke O (December 2002). "Structural requirements for interactions between leucine-sorting signals and clathrin-associated adaptor protein complex AP3". The Journal of Biological Chemistry. 277 (49): 47436–43. doi:10.1074/jbc.M207149200. PMID 12370188.
• Nie Z, Boehm M, Boja ES, Vass WC, Bonifacino JS, Fales HM, Randazzo PA (September 2003). "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1". Developmental Cell. 5 (3): 513–21. doi:10.1016/S1534-5807(03)00234-X. PMID 12967569.
• Salazar G, Love R, Werner E, Doucette MM, Cheng S, Levey A, Faundez V (February 2004). "The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation". Molecular Biology of the Cell. 15 (2): 575–87. doi:10.1091/mbc.E03-06-0401. PMC 329249. PMID 14657250.
• Lefrançois S, Janvier K, Boehm M, Ooi CE, Bonifacino JS (October 2004). "An ear-core interaction regulates the recruitment of the AP-3 complex to membranes". Developmental Cell. 7 (4): 619–25. doi:10.1016/j.devcel.2004.08.009. PMID 15469849.