AP1AR

AP-1 complex-associated regulatory protein (Gamma1-adaptin brefeldin A resistance protein) is a protein that in humans is encoded by the AP1AR gene.[5][6]

AP1AR
Identifiers
Aliases	AP1AR, 2C18, C4orf16, GBAR, gamma-BAR, PRO0971, adaptor related protein complex 1 associated regulatory protein
External IDs	OMIM: 610851 MGI: 2384822 HomoloGene: 10236 GeneCards: AP1AR
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q25 Start 112,231,740 bp[1] End 112,273,110 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G2 Start 127,807,007 bp[2] End 127,837,523 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • kinesin binding • AP-1 adaptor complex binding Cellular component • late endosome • Golgi apparatus • early endosome • transport vesicle • cytosol • endosome Biological process • protein transport • cellular protein localization • negative regulation of cell motility • negative regulation of substrate adhesion-dependent cell spreading • regulation of Arp2/3 complex-mediated actin nucleation • negative regulation of receptor recycling • vesicle targeting, trans-Golgi to endosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55435	211556
Ensembl	ENSG00000138660	ENSMUSG00000074238
UniProt	Q63HQ0	n/a
RefSeq (mRNA)	NM_001128426 NM_018569	NM_145964 NM_001346718
RefSeq (protein)	NP_001121898 NP_061039	n/a
Location (UCSC)	Chr 4: 112.23 – 112.27 Mb	Chr 3: 127.81 – 127.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000138660 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074238 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Neubrand VE, Will RD, Mobius W, Poustka A, Wiemann S, Schu P, Dotti CG, Pepperkok R, Simpson JC (Apr 2005). "Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking". EMBO J. 24 (6): 1122–33. doi:10.1038/sj.emboj.7600600. PMC 556403. PMID 15775984.
6. "Entrez Gene: C4orf16 chromosome 4 open reading frame 16".

External links

• Human AP1AR genome location and AP1AR gene details page in the UCSC Genome Browser.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.