STX12

Syntaxin-12 is a protein that in humans is encoded by the STX12 gene.[4][5]

STX12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DNX
Identifiers
Aliases	STX12, STX13, STX14, syntaxin 12
External IDs	OMIM: 606892 MGI: 1931027 HomoloGene: 128192 GeneCards: STX12
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 27,773,219 bp[1] End 27,824,443 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SNAP receptor activity • GO:0001948 protein binding • SNARE binding Cellular component • integral component of membrane • vesicle • endosome • Golgi apparatus • membrane • Golgi membrane • BLOC-1 complex • pre-autophagosomal structure • SNARE complex • phagocytic vesicle • membrane raft • endosome membrane • endomembrane system • early endosome membrane • recycling endosome membrane • synaptic vesicle • integral component of synaptic vesicle membrane • postsynaptic recycling endosome Biological process • protein stabilization • autophagosome assembly • vesicle docking • cholesterol efflux • protein transport • intracellular protein transport • vesicle fusion • vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23673	100226
Ensembl	ENSG00000117758	n/a
UniProt	Q86Y82	Q9ER00
RefSeq (mRNA)	NM_177424	NM_133887
RefSeq (protein)	NP_803173	NP_598648
Location (UCSC)	Chr 1: 27.77 – 27.82 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

STX12 has been shown to interact with PLDN.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000117758 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Tang BL, Tan AE, Lim LK, Lee SS, Low DY, Hong W (March 1998). "Syntaxin 12, a member of the syntaxin family localized to the endosome". The Journal of Biological Chemistry. 273 (12): 6944–50. doi:10.1074/jbc.273.12.6944. PMID 9507000.
5. "Entrez Gene: STX12 syntaxin 12".
6. Huang L, Kuo YM, Gitschier J (November 1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nature Genetics. 23 (3): 329–32. doi:10.1038/15507. PMID 10610180.

Further reading

• Falcón-Pérez JM, Dell'Angelica EC (April 2002). "The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis". Pigment Cell Research. 15 (2): 82–6. doi:10.1034/j.1600-0749.2002.1r082.x. PMID 11936273.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH (April 1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". The Journal of Biological Chemistry. 273 (17): 10317–24. doi:10.1074/jbc.273.17.10317. PMID 9553086.
• Prekeris R, Klumperman J, Chen YA, Scheller RH (November 1998). "Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes". The Journal of Cell Biology. 143 (4): 957–71. doi:10.1083/jcb.143.4.957. PMC 2132958. PMID 9817754.
• Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (December 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
• McBride HM, Rybin V, Murphy C, Giner A, Teasdale R, Zerial M (August 1999). "Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13". Cell. 98 (3): 377–86. doi:10.1016/S0092-8674(00)81966-2. PMID 10458612.
• Huang L, Kuo YM, Gitschier J (November 1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nature Genetics. 23 (3): 329–32. doi:10.1038/15507. PMID 10610180.
• Minakami R, Kato A, Sugiyama H (June 2000). "Interaction of Vesl-1L/Homer 1c with syntaxin 13". Biochemical and Biophysical Research Communications. 272 (2): 466–71. doi:10.1006/bbrc.2000.2777. PMID 10833436.
• Hirling H, Steiner P, Chaperon C, Marsault R, Regazzi R, Catsicas S (June 2000). "Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking". The European Journal of Neuroscience. 12 (6): 1913–23. doi:10.1046/j.1460-9568.2000.00076.x. PMID 10886332.
• Steiner P, Sarria JC, Glauser L, Magnin S, Catsicas S, Hirling H (June 2002). "Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD". The Journal of Cell Biology. 157 (7): 1197–209. doi:10.1083/jcb.200202022. PMC 2173541. PMID 12070131.
• Sun W, Yan Q, Vida TA, Bean AJ (July 2003). "Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex". The Journal of Cell Biology. 162 (1): 125–37. doi:10.1083/jcb.200302083. PMC 2172712. PMID 12847087.
• Bared SM, Buechler C, Boettcher A, Dayoub R, Sigruener A, Grandl M, Rudolph C, Dada A, Schmitz G (December 2004). "Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells". Molecular Biology of the Cell. 15 (12): 5399–407. doi:10.1091/mbc.E04-03-0182. PMC 532019. PMID 15469992.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Syntaxin-12