SYNCRIP

Synaptotagmin binding, cytoplasmic RNA interacting protein, also known as Heterogeneous nuclear ribonucleoprotein Q is a protein that in humans is encoded by the SYNCRIP gene.[5][6][7]

SYNCRIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DGU, 2MXT, 2NBB
Identifiers
Aliases	SYNCRIP, GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q, synaptotagmin binding cytoplasmic RNA interacting protein
External IDs	OMIM: 616686 MGI: 1891690 HomoloGene: 4648 GeneCards: SYNCRIP
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q14.3 Start 85,607,785 bp[1] End 85,643,792 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.1 Start 88,447,009 bp[2] End 88,482,574 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • poly(A) binding • GO:0001948 protein binding • nucleic acid binding • RNA binding • mRNA binding • mRNA 5'-UTR binding Cellular component • CRD-mediated mRNA stability complex • cytoplasm • catalytic step 2 spliceosome • histone pre-mRNA 3'end processing complex • intracellular membrane-bounded organelle • nucleoplasm • endoplasmic reticulum • GAIT complex • spliceosomal complex • cell nucleus • membrane • ribonucleoprotein Biological process • CRD-mediated mRNA stabilization • mRNA splicing, via spliceosome • RNA processing • negative regulation of translation • mRNA processing • osteoblast differentiation • RNA splicing • cellular response to interferon-gamma • GO:0022415 viral process • regulation of translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10492	56403
Ensembl	ENSG00000135316	ENSMUSG00000032423
UniProt	O60506	Q7TMK9
RefSeq (mRNA)	NM_001159673 NM_001159674 NM_001159675 NM_001159676 NM_001159677 NM_001253771 NM_006372	NM_001284328 NM_019666 NM_019796 NM_001311113
RefSeq (protein)	NP_001153145 NP_001153146 NP_001153147 NP_001153148 NP_001153149 NP_001240700 NP_006363	NP_001271257 NP_001298042 NP_062640 NP_062770
Location (UCSC)	Chr 6: 85.61 – 85.64 Mb	Chr 9: 88.45 – 88.48 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SYNCRIP has been shown to interact with ACF,[6][8] APOBEC1,[6] SYT7[9] and SYT9,[9]

References

1. GRCh38: Ensembl release 89: ENSG00000135316 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032423 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Harris CE, Boden RA, Astell CR (January 1999). "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice". Journal of Virology. 73 (1): 72–80. doi:10.1128/JVI.73.1.72-80.1999. PMC 103810. PMID 9847309.
6. Lau PP, Chang BH, Chan L (April 2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome". Biochemical and Biophysical Research Communications. 282 (4): 977–83. doi:10.1006/bbrc.2001.4679. PMID 11352648.
7. "Entrez Gene: SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein".
8. Blanc V, Navaratnam N, Henderson JO, Anant S, Kennedy S, Jarmuz A, Scott J, Davidson NO (March 2001). "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing". The Journal of Biological Chemistry. 276 (13): 10272–83. doi:10.1074/jbc.M006435200. PMID 11134005.
9. Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Fu C, Chan AC (October 1997). "Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation". The Journal of Biological Chemistry. 272 (43): 27362–8. doi:10.1074/jbc.272.43.27362. PMID 9341187.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (September 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Grosset C, Chen CY, Xu N, Sonenberg N, Jacquemin-Sablon H, Shyu AB (September 2000). "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex". Cell. 103 (1): 29–40. doi:10.1016/S0092-8674(00)00102-1. PMID 11051545.
• Blanc V, Navaratnam N, Henderson JO, Anant S, Kennedy S, Jarmuz A, Scott J, Davidson NO (March 2001). "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing". The Journal of Biological Chemistry. 276 (13): 10272–83. doi:10.1074/jbc.M006435200. PMID 11134005.
• Mourelatos Z, Abel L, Yong J, Kataoka N, Dreyfuss G (October 2001). "SMN interacts with a novel family of hnRNP and spliceosomal proteins". The EMBO Journal. 20 (19): 5443–52. doi:10.1093/emboj/20.19.5443. PMC 125643. PMID 11574476.
• Rossoll W, Kröning AK, Ohndorf UM, Steegborn C, Jablonka S, Sendtner M (January 2002). "Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?". Human Molecular Genetics. 11 (1): 93–105. doi:10.1093/hmg/11.1.93. PMID 11773003.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Hresko RC, Mueckler M (July 2002). "Identification of pp68 as the Tyrosine-phosphorylated Form of SYNCRIP/NSAP1. A cytoplasmic RNA-binding protein". The Journal of Biological Chemistry. 277 (28): 25233–8. doi:10.1074/jbc.M202556200. PMID 11994298.
• Carty SM, Greenleaf AL (August 2002). "Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing". Molecular & Cellular Proteomics. 1 (8): 598–610. doi:10.1074/mcp.M200029-MCP200. PMID 12376575.
• Angenstein F, Evans AM, Settlage RE, Moran ST, Ling SC, Klintsova AY, Shabanowitz J, Hunt DF, Greenough WT (October 2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". The Journal of Neuroscience. 22 (20): 8827–37. doi:10.1523/JNEUROSCI.22-20-08827.2002. PMC 6757688. PMID 12388589.
• Hinsby AM, Olsen JV, Bennett KL, Mann M (January 2003). "Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry". Molecular & Cellular Proteomics. 2 (1): 29–36. CiteSeerX 10.1.1.580.5376. doi:10.1074/mcp.M200075-MCP200. PMID 12601080.
• Moraes KC, Quaresma AJ, Maehnss K, Kobarg J (January 2003). "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D)". Biological Chemistry. 384 (1): 25–37. doi:10.1515/BC.2003.004. PMID 12674497.
• Kim JH, Paek KY, Ha SH, Cho S, Choi K, Kim CS, Ryu SH, Jang SK (September 2004). "A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon". Molecular and Cellular Biology. 24 (18): 7878–90. doi:10.1128/MCB.24.18.7878-7890.2004. PMC 515056. PMID 15340051.
• Quaresma AJ, Bressan GC, Gava LM, Lanza DC, Ramos CH, Kobarg J (April 2009). "Human hnRNP Q re-localizes to cytoplasmic granules upon PMA, thapsigargin, arsenite and heat-shock treatments". Experimental Cell Research. 315 (6): 968–80. doi:10.1016/j.yexcr.2009.01.012. PMID 19331829.
• Moraes KC, Quaresma AJ, Maehnss K, Kobarg J (January 2003). "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D)". Biological Chemistry. 384 (1): 25–37. doi:10.1515/BC.2003.004. ISSN 1431-6730. PMID 12674497.