STX16

Syntaxin-16 is a protein that in humans is encoded by the STX16 gene.[5][6][7][8]

STX16
Identifiers
Aliases	STX16, SYN16, syntaxin 16
External IDs	OMIM: 603666 MGI: 1923396 HomoloGene: 2791 GeneCards: STX16
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.32 Start 58,651,253 bp[1] End 58,679,526 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H4 Start 174,076,308 bp[2] End 174,099,771 bp[2]
Gene ontology Molecular function • SNAP receptor activity • GO:0001948 protein binding • syntaxin binding • SNARE binding Cellular component • cytoplasm • integral component of membrane • Golgi apparatus • membrane • intracellular membrane-bounded organelle • Golgi cisterna • focal adhesion • trans-Golgi network • SNARE complex • endoplasmic reticulum • perinuclear region of cytoplasm • cytosol • trans-Golgi network membrane • Golgi membrane • endomembrane system • integral component of synaptic vesicle membrane Biological process • vesicle docking • retrograde transport, endosome to Golgi • protein transport • intracellular protein transport • vesicle fusion • Golgi ribbon formation • vesicle-mediated transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8675	228960
Ensembl	ENSG00000124222	ENSMUSG00000027522
UniProt	O14662	Q8BVI5
RefSeq (mRNA)	NM_001001433 NM_001001434 NM_001134772 NM_001134773 NM_001204868 NM_003763	NM_001102423 NM_001102424 NM_001102425 NM_172675 NM_001363029 NM_001363030 NM_001363031
RefSeq (protein)	NP_001001433 NP_001128244 NP_001128245 NP_001191797 NP_003754	NP_001095893 NP_001095894 NP_001095895 NP_766263 NP_001349958 NP_001349959 NP_001349960
Location (UCSC)	Chr 20: 58.65 – 58.68 Mb	Chr 2: 174.08 – 174.1 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

It has been associated with pseudohypoparathyroidism type Ib. Losing this gene causes loss of methylation at GNAS1 exon A/B.[7]

Interactions

STX16 has been shown to interact with VAMP4.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000124222 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027522 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tang BL, Low DY, Lee SS, Tan AE, Hong W (Jan 1998). "Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins". Biochemical and Biophysical Research Communications. 242 (3): 673–9. doi:10.1006/bbrc.1997.8029. PMID 9464276.
6. Simonsen A, Bremnes B, Rønning E, Aasland R, Stenmark H (Mar 1998). "Syntaxin-16, a putative Golgi t-SNARE". European Journal of Cell Biology. 75 (3): 223–31. doi:10.1016/S0171-9335(98)80116-7. PMID 9587053.
7. Linglart A, Gensure RC, Olney RC, Jüppner H, Bastepe M (May 2005). "A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS". American Journal of Human Genetics. 76 (5): 804–14. doi:10.1086/429932. PMC 1199370. PMID 15800843.
8. "Entrez Gene: STX16 syntaxin 16".
9. Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.

Further reading

• Yu Y, Zhang C, Zhou G, Wu S, Qu X, Wei H, Xing G, Dong C, Zhai Y, Wan J, Ouyang S, Li L, Zhang S, Zhou K, Zhang Y, Wu C, He F (Aug 2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Research. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
• Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
• Dulubova I, Yamaguchi T, Gao Y, Min SW, Huryeva I, Südhof TC, Rizo J (Jul 2002). "How Tlg2p/syntaxin 16 'snares' Vps45". The EMBO Journal. 21 (14): 3620–31. doi:10.1093/emboj/cdf381. PMC 126126. PMID 12110575.
• Clark AG, Glanowski S, Nielsen R, Thomas PD, Kejariwal A, Todd MA, Tanenbaum DM, Civello D, Lu F, Murphy B, Ferriera S, Wang G, Zheng X, White TJ, Sninsky JJ, Adams MD, Cargill M (Dec 2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
• Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, Hong W (Sep 2004). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network". Molecular Biology of the Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Amessou M, Fradagrada A, Falguières T, Lord JM, Smith DC, Roberts LM, Lamaze C, Johannes L (Apr 2007). "Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins". Journal of Cell Science. 120 (Pt 8): 1457–68. doi:10.1242/jcs.03436. PMC 1863825. PMID 17389686.