Progestogen-only injectable contraceptive

Progestogen-only injectable contraceptives (POICs) are a form of hormonal contraception and progestogen-only contraception that are administered by injection and providing long-lasting birth control.[2][3] As opposed to combined injectable contraceptives, they contain only a progestogen without an estrogen, and include two progestin preparations:[2][3]

Long-acting reversible contraceptives (LARC)
Background
TypeHormonal
First use1957[1]
Pregnancy rates (first year)
Perfect use?
Typical use?
Usage
ReversibilityYes
User reminders?
Advantages and disadvantages
STI protectionNo

Research

Progestogens that have been studied for potential use as POICs but were never marketed as such include the progesterone derivatives algestone acetophenide (dihydroxyprogesterone acetophenide) (100 mg/month), chlormadinone acetate (250 mg/3 months), hydroxyprogesterone caproate (250–500 mg/month), gestonorone caproate (2.5–200 mg/1–2 months), and oxogestone phenpropionate (50–75 mg/month), and the testosterone derivatives lynestrenol phenylpropionate (25–75 mg/month), levonorgestrel butanoate, levonorgestrel cyclobutylcarboxylate, and levonorgestrel cyclopropylcarboxylate.[6][7] Some of these have been introduced for use in combined injectable contraceptives instead.[6][8][9]

gollark: I think it could just directly DM the user.
gollark: Oh yes, by illicitly using admin powers.
gollark: You did? How?
gollark: But I don't know the category.
gollark: QUESTION to all ABR users: if the channel a reminder was sent to does not exist, what do?

See also

References
  1. Singh M, Saxena BB, Singh R, Kaplan J, Ledger WJ (1997). "Contraceptive efficacy of norethindrone encapsulated in injectable biodegradable poly-dl-lactide-co-glycolide microspheres (NET-90): phase III clinical study". Advances in Contraception. 13 (1): 1–11. PMID 9181181. In 1957, Karl Junkmann developed norethindrone enanthate (NET-EN or Noristeroir), the first injectable contraceptive which was injected every two months [1].
  2. P. F. A. van Look; Kristian Heggenhougen; Stella R. Quah (January 2011). Sexual and Reproductive Health: A Public Health Perspective. Academic Press. pp. 82–. ISBN 978-0-12-385009-6.
  3. Nagrath Arun; Malhotra Narendra; Seth Shikha (15 December 2012). Progress in Obstetrics and Gynecology--3. Jaypee Brothers Medical Publishers Pvt. Ltd. pp. 416–. ISBN 978-93-5090-575-3.
  4. Mary Lee; Archana Desai (2007). Gibaldi's Drug Delivery Systems in Pharmaceutical Care. ASHP. pp. 328–. ISBN 978-1-58528-136-7.
  5. Chaudhuri (1 January 2007). Practice Of Fertility Control: A Comprehensive Manual (7Th Edition). Elsevier India. pp. 154–. ISBN 978-81-312-1150-2.
  6. Mokhtar K. Toppozada (1983). "Monthly Injectable Contraceptives". In Alfredo Goldsmith; Mokhtar Toppozada (eds.). Long-Acting Contraception. pp. 93–103. OCLC 35018604.
  7. Dr. S. S. Kadam (July 2007). PRINCIPLES OF MEDICINAL CHEMISTRY Vol. - II. Pragati Books Pvt. Ltd. pp. 381–. ISBN 978-81-85790-03-9.
  8. Benagiano, G., & Merialdi, M. (2011). Carl Djerassi and the World Health Organisation special programme of research in human reproduction. Journal für Reproduktionsmedizin und Endokrinologie-Journal of Reproductive Medicine and Endocrinology, 8(1), 10-13. http://www.kup.at/kup/pdf/10163.pdf
  9. Toppozada M (June 1977). "The clinical use of monthly injectable contraceptive preparations". Obstet Gynecol Surv. 32 (6): 335–47. doi:10.1097/00006254-197706000-00001. PMID 865726.
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