Desmoglein

The desmogleins are a family of desmosomal cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another.

Desmoglein
Identifiers
SymbolDSG
InterProIPR009123
Membranome243

Pathology

Desmogleins are targeted in the autoimmune disease pemphigus.[1][2][3]

Desmoglein proteins are a type of cadherin, which is a transmembrane protein that binds with other cadherins to form junctions known as desmosomes between cells. These desmoglein proteins thus hold cells together, but when the body starts producing antibodies against desmoglein, these junctions break down, and this results in subsequent blister or vesicle formation.[4][5]

gollark: As you can see, centre-justification follows from the combination of left- and right-justification.
gollark: Left-justification:> Left-wing politics supports social equality and egalitarianism, often in critique of social hierarchy.[1][2][3][4] Left-wing politics typically involves a concern for those in society whom its adherents perceive as disadvantaged relative to others as well as a belief that there are unjustified inequalities that need to be reduced or abolished.[1] According to emeritus professor of economics Barry Clark, left-wing supporters "claim that human development flourishes when individuals engage in cooperative, mutually respectful relations that can thrive only when excessive differences in status, power, and wealth are eliminated."[5] No language (except esoteric apioforms) *truly* lacks generics. Typically, they have generics, but limited to a few "blessed" built-in data types; in C, arrays and pointers; in Go, maps, slices and channels. This of course creates vast inequality between the built-in types and the compiler writers and the average programmers with their user-defined data types, which cannot be generic. Typically, users of the language are forced to either manually monomorphise, or use type-unsafe approaches such as `void*`. Both merely perpetuate an unjust system which must be abolished.
gollark: Anyway, center-justify... centrism is about being precisely in the middle of the left and right options. I will imminently left-justify it, so centre-justification WILL follow.
gollark: Social hierarchies are literal hierarchies.
gollark: Hmm. Apparently,> Right-wing politics embraces the view that certain social orders and hierarchies are inevitable, natural, normal, or desirable,[1][2][3] typically supporting this position on the basis of natural law, economics, or tradition.[4]:693, 721[5][6][7][8][9] Hierarchy and inequality may be seen as natural results of traditional social differences[10][11] or competition in market economies.[12][13][14] The term right-wing can generally refer to "the conservative or reactionary section of a political party or system".[15] Obviously, generics should exist in all programming languages ever, since they have existed for quite a while and been implemented rather frequently, and allow you to construct hierarchical data structures like trees which are able to contain any type.

References
  1. Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D (November 2005). "Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction". J. Clin. Invest. 115 (11): 3157–65. doi:10.1172/JCI23475. PMC 1242188. PMID 16211092.
  2. Kljuic A, Bazzi H, Sundberg JP, et al. (April 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris". Cell. 113 (2): 249–60. doi:10.1016/S0092-8674(03)00273-3. PMID 12705872.
  3. Müller R, Heber B, Hashimoto T, et al. (May 2009). "Autoantibodies against desmocollins in European patients with pemphigus". Clin. Exp. Dermatol. 34 (8): 898–903. doi:10.1111/j.1365-2230.2009.03241.x. PMID 19456767.
  4. A Clinician's Guide to Pemphigus Vulgarishttp://www.springer.com/gp/book/9783319677583
  5. Bolognia JL, Jorizzo JL, Schaffer JV, editors. Dermatology. 3rd ed. Philadelphia: Elsevier Saunders; 2012


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.