P2RX1

P2X purinoceptor 1 is a protein that in humans is encoded by the P2RX1 gene.[5]

P2RX1
Identifiers
Aliases	P2RX1, P2X1, purinergic receptor P2X 1
External IDs	OMIM: 600845 MGI: 1098235 HomoloGene: 1921 GeneCards: P2RX1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 3,896,592 bp[1] End 3,916,476 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B4|11 45.09 cM Start 72,999,103 bp[2] End 73,015,200 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • zinc ion binding • purinergic nucleotide receptor activity • ion channel activity • drug binding • cation channel activity • ATP binding • extracellular ATP-gated cation channel activity • ATP-gated ion channel activity Cellular component • integral component of membrane • postsynaptic membrane • membrane • cell membrane • integral component of nuclear inner membrane • integral component of plasma membrane • membrane raft • neuron projection • secretory granule membrane • specific granule membrane • external side of plasma membrane • macromolecular complex • glutamatergic synapse • integral component of postsynaptic membrane • integral component of presynaptic active zone membrane Biological process • response to ATP • regulation of calcium ion transport • synaptic transmission, glutamatergic • protein heterooligomerization • regulation of smooth muscle contraction • vasoconstriction • ceramide biosynthetic process • serotonin secretion by platelet • blood coagulation • ion transport • response to organic substance • cation transmembrane transport • platelet activation • regulation of blood pressure • regulation of vasoconstriction • positive regulation of ion transport • insemination • protein homooligomerization • activation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of vascular smooth muscle contraction • neuronal action potential • signal transduction • apoptotic process • purinergic nucleotide receptor signaling pathway • neutrophil degranulation • excitatory postsynaptic potential • regulation of presynaptic cytosolic calcium ion concentration • regulation of synaptic vesicle exocytosis • cation transport • ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5023	18436
Ensembl	ENSG00000108405	ENSMUSG00000020787
UniProt	P51575	P51576
RefSeq (mRNA)	NM_002558	NM_008771
RefSeq (protein)	NP_002549	NP_032797
Location (UCSC)	Chr 17: 3.9 – 3.92 Mb	Chr 11: 73 – 73.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.[6]

See also

• P2X receptor

References

1. GRCh38: Ensembl release 89: ENSG00000108405 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020787 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Valera S, Talabot F, Evans RJ, Gos A, Antonarakis SE, Morris MA, Buell GN (Nov 1996). "Characterization and chromosomal localization of a human P2X receptor from the urinary bladder". Receptors Channels. 3 (4): 283–9. PMID 8834001.
6. "Entrez Gene: P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1".

Further reading

• North RA (2002). "Molecular physiology of P2X receptors". Physiol. Rev. 82 (4): 1013–67. doi:10.1152/physrev.00015.2002. PMID 12270951.
• Longhurst PA, Schwegel T, Folander K, Swanson R (1996). "The human P2x1 receptor: molecular cloning, tissue distribution, and localization to chromosome 17". Biochim. Biophys. Acta. 1308 (3): 185–8. doi:10.1016/0167-4781(96)00112-1. PMID 8809107.
• Clifford EE, Parker K, Humphreys BD, et al. (1998). "The P2X1 receptor, an adenosine triphosphate-gated cation channel, is expressed in human platelets but not in human blood leukocytes". Blood. 91 (9): 3172–81. doi:10.1182/blood.V91.9.3172. PMID 9558372.
• Sun B, Li J, Okahara K, Kambayashi J (1998). "P2X1 purinoceptor in human platelets. Molecular cloning and functional characterization after heterologous expression". J. Biol. Chem. 273 (19): 11544–7. doi:10.1074/jbc.273.19.11544. PMID 9565569.
• Mulryan K, Gitterman DP, Lewis CJ, et al. (2000). "Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors". Nature. 403 (6765): 86–9. Bibcode:2000Natur.403...86M. doi:10.1038/47495. PMID 10638758.
• Oury C, Toth-Zsamboki E, Van Geet C, et al. (2000). "A natural dominant negative P2X1 receptor due to deletion of a single amino acid residue". J. Biol. Chem. 275 (30): 22611–4. doi:10.1074/jbc.C000305200. PMID 10816552.
• Dhulipala PD, Lianos EA, Kotlikoff MI (2001). "Regulation of human P2X1 promoter activity by beta helix-loop-helix factors in smooth muscle cells". Gene. 269 (1–2): 167–75. doi:10.1016/S0378-1119(01)00442-5. PMID 11376948.
• Ennion SJ, Evans RJ (2002). "Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface". Mol. Pharmacol. 61 (2): 303–11. doi:10.1124/mol.61.2.303. PMID 11809854.
• Vial C, Rolf MG, Mahaut-Smith MP, Evans RJ (2002). "A study of P2X1 receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors". Br. J. Pharmacol. 135 (2): 363–72. doi:10.1038/sj.bjp.0704486. PMC 1573149. PMID 11815371.
• Oury C, Toth-Zsamboki E, Thys C, et al. (2003). "The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen". Thromb. Haemost. 86 (5): 1264–71. PMID 11816716.
• Toth-Zsamboki E, Oury C, Watanabe H, et al. (2002). "The intracellular tyrosine residues of the ATP-gated P2X(1) ion channel are essential for its function". FEBS Lett. 524 (1–3): 15–9. doi:10.1016/S0014-5793(02)02987-3. PMID 12135734.
• Oury C, Toth-Zsamboki E, Vermylen J, Hoylaerts MF (2002). "P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen". Blood. 100 (7): 2499–505. doi:10.1182/blood-2002-03-0812. PMID 12239162.
• Rolf MG, Mahaut-Smith MP (2003). "Effects of enhanced P2X₁ receptor Ca²⁺ influx on functional responses in human platelets". Thromb. Haemost. 88 (3): 495–502. doi:10.1055/s-0037-1613243. PMID 12353081.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Valdecantos P, Briones R, Moya P, et al. (2003). "Pharmacological identification of P2X1, P2X4 and P2X7 nucleotide receptors in the smooth muscles of human umbilical cord and chorionic blood vessels". Placenta. 24 (1): 17–26. doi:10.1053/plac.2002.0862. PMID 12495655.
• Oury C, Kuijpers MJ, Toth-Zsamboki E, et al. (2003). "Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype". Blood. 101 (10): 3969–76. doi:10.1182/blood-2002-10-3215. PMID 12521992.
• Wang L, Andersson M, Karlsson L, et al. (2004). "Increased mitogenic and decreased contractile P2 receptors in smooth muscle cells by shear stress in human vessels with intact endothelium". Arterioscler. Thromb. Vasc. Biol. 23 (8): 1370–6. doi:10.1161/01.ATV.0000080350.37408.5A. PMID 12791671.
• Vial C, Pitt SJ, Roberts J, et al. (2004). "Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis". Blood. 102 (10): 3646–51. doi:10.1182/blood-2003-06-1963. PMID 12907444.

External links

• P2RX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.