GABRR1

Gamma-aminobutyric acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene.[5][6][7]

GABRR1
Identifiers
Aliases	GABRR1, gamma-aminobutyric acid type A receptor rho1 subunit, gamma-aminobutyric acid type A receptor subunit rho1
External IDs	OMIM: 137161 MGI: 95625 HomoloGene: 20470 GeneCards: GABRR1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 89,177,504 bp[1] End 89,231,278 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 14.68 cM Start 33,132,521 bp[2] End 33,163,588 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • chloride channel activity • extracellular ligand-gated ion channel activity • GABA-A receptor activity • ion channel activity • transmembrane signaling receptor activity • ligand-gated ion channel activity involved in regulation of presynaptic membrane potential • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component • integral component of membrane • GABA-A receptor complex • postsynaptic membrane • membrane • cell membrane • synapse • integral component of plasma membrane • chloride channel complex • cell junction • neuron projection • glutamatergic synapse • GABA-ergic synapse Biological process • gamma-aminobutyric acid signaling pathway • chloride transmembrane transport • ion transport • chloride transport • chemical synaptic transmission • ion transmembrane transport • signal transduction • regulation of membrane potential • nervous system process • postsynaptic potential • regulation of presynaptic membrane potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2569	14408
Ensembl	ENSG00000146276	ENSMUSG00000028280
UniProt	P24046	P56475
RefSeq (mRNA)	NM_001256703 NM_001256704 NM_001267582 NM_002042	NM_008075
RefSeq (protein)	NP_001243632 NP_001243633 NP_001254511 NP_002033	NP_032101
Location (UCSC)	Chr 6: 89.18 – 89.23 Mb	Chr 4: 33.13 – 33.16 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.[7]

See also

• GABA_A-ρ receptor

References

1. GRCh38: Ensembl release 89: ENSG00000146276 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028280 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cutting GR, Lu L, O'Hara BF, Kasch LM, Montrose-Rafizadeh C, Donovan DM, Shimada S, Antonarakis SE, Guggino WB, Uhl GR, et al. (May 1991). "Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina". Proc Natl Acad Sci U S A. 88 (7): 2673–2677. doi:10.1073/pnas.88.7.2673. PMC 51300. PMID 1849271.
6. Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR (May 1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4". Genomics. 12 (4): 801–806. doi:10.1016/0888-7543(92)90312-G. PMID 1315307.
7. "Entrez Gene: GABRR1 gamma-aminobutyric acid (GABA) receptor, rho 1".

Further reading

• Wang TL, Hackam A, Guggino WB, Cutting GR (1995). "A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors". J. Neurosci. 15 (11): 7684–7691. doi:10.1523/jneurosci.15-11-07684.1995. PMC 6578093. PMID 7472519.
• Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction". J. Biol. Chem. 272 (21): 13750–13757. doi:10.1074/jbc.272.21.13750. PMID 9153229.
• Kusama T, Hatama K, Sakurai M, et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation". Neurosci. Lett. 255 (1): 17–20. doi:10.1016/S0304-3940(98)00696-X. PMID 9839716.
• Hanley JG, Koulen P, Bedford F, et al. (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses". Nature. 397 (6714): 66–69. doi:10.1038/16258. PMID 9892354.
• Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta. 1447 (2–3): 307–312. doi:10.1016/S0167-4781(99)00167-0. PMID 10542332.
• Hanley JG, Jones EM, Moss SJ (2000). "GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1". J. Biol. Chem. 275 (2): 840–846. doi:10.1074/jbc.275.2.840. PMID 10625616.
• Filippova N, Sedelnikova A, Zong Y, et al. (2000). "Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C". Mol. Pharmacol. 57 (5): 847–856. PMID 10779366.
• Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–8650. doi:10.1523/jneurosci.20-23-08643.2000. PMC 6773065. PMID 11102469.
• Wang QW, Li ZW, Wang F, Yang JQ (2002). "Modulation by divalent cations of GABA rho 1 receptor from human retina expressed in Xenopus oocytes". Biomed. Environ. Sci. 14 (4): 269–277. PMID 11862606.
• Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor". Int. J. Dev. Neurosci. 20 (3–5): 237–246. doi:10.1016/S0736-5748(02)00037-0. PMID 12175859.
• Torres VI, Weiss DS (2003). "Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening". J. Biol. Chem. 277 (46): 43741–43748. doi:10.1074/jbc.M202007200. PMID 12226075.
• Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–6135. doi:10.1074/jbc.M205162200. PMID 12431995.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. doi:10.1038/nature02055. PMID 14574404.
• Boué-Grabot E, Emerit MB, Toulmé E, et al. (2004). "Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels". J. Biol. Chem. 279 (8): 6967–6975. doi:10.1074/jbc.M307772200. PMID 14660627.
• Martínez-Torres A, Miledi R (2004). "A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism". Arch. Med. Res. 35 (3): 194–198. doi:10.1016/j.arcmed.2003.12.002. PMID 15163459.
• Sedelnikova A, Smith CD, Zakharkin SO, et al. (2005). "Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model". J. Biol. Chem. 280 (2): 1535–1542. doi:10.1074/jbc.M409908200. PMID 15548535.
• Song XQ, Meng F, Ramsey DJ, et al. (2006). "The GABA rho1 subunit interacts with a cellular retinoic acid binding protein in mammalian retina". Neuroscience. 136 (2): 467–475. doi:10.1016/j.neuroscience.2005.08.018. PMID 16198491.

External links

• GABRR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.