HTR3C

5-hydroxytryptamine receptor 3C is a protein that in humans is encoded by the HTR3C gene.[3][3][4] The protein encoded by this gene is a subunit of the 5-HT3 receptor.[4]

HTR3C
Identifiers
Aliases	HTR3C, 5-hydroxytryptamine receptor 3C
External IDs	OMIM: 610121 HomoloGene: 50847 GeneCards: HTR3C
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 184,053,047 bp[1] End 184,060,673 bp[1]
Gene ontology Molecular function • GO:0001948 protein binding • extracellular ligand-gated ion channel activity • serotonin-gated cation-selective channel activity • ion channel activity • transmembrane signaling receptor activity Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane • neuron projection • synapse Biological process • ion transport • signal transduction • ion transmembrane transport • serotonin receptor signaling pathway • chemical synaptic transmission • regulation of membrane potential • nervous system process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	170572	n/a
Ensembl	ENSG00000178084	n/a
UniProt	Q8WXA8	n/a
RefSeq (mRNA)	NM_130770	n/a
RefSeq (protein)	NP_570126	n/a
Location (UCSC)	Chr 3: 184.05 – 184.06 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000178084 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Niesler B, Frank B, Kapeller J, Rappold GA (Jun 2003). "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E". Gene. 310: 101–11. doi:10.1016/S0378-1119(03)00503-1. PMID 12801637.
4. Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ (May 2004). "The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance". Biochem Soc Trans. 32 (Pt3): 547–52. doi:10.1042/BST0320547. PMID 15157181.

Further reading

• Karnovsky AM, Gotow LF, McKinley DD, et al. (2003). "A cluster of novel serotonin receptor 3-like genes on human chromosome 3". Gene. 319: 137–48. doi:10.1016/S0378-1119(03)00803-5. PMID 14597179.
• Fasching PA, Kollmannsberger B, Strissel PL, et al. (2008). "Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy". J. Cancer Res. Clin. Oncol. 134 (10): 1079–86. doi:10.1007/s00432-008-0387-1. PMID 18389280.
• Ward MB, Kotasek D, McKinnon RA (2008). "Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy". Pharmacogenomics. 9 (8): 1027–33. doi:10.2217/14622416.9.8.1027. PMID 18681779.

External links

• HTR3C+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)