GLRA2

Glycine receptor subunit alpha-2 is a protein that in humans is encoded by the GLRA2 gene.[5]

GLRA2
Identifiers
Aliases	GLRA2, GLR, glycine receptor alpha 2
External IDs	OMIM: 305990 MGI: 95748 HomoloGene: 31070 GeneCards: GLRA2
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 14,529,298 bp[1] End 14,731,812 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F5|X 76.75 cM Start 165,129,017 bp[2] End 165,327,393 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • glycine binding • transmitter-gated ion channel activity • chloride channel activity • glycine-gated chloride ion channel activity • extracellular-glycine-gated chloride channel activity • extracellular ligand-gated ion channel activity • ion channel activity • transmembrane signaling receptor activity • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component • synapse • integral component of membrane • cell projection • cell junction • integral component of plasma membrane • postsynaptic membrane • membrane • chloride channel complex • cell membrane • neuron projection • glycinergic synapse Biological process • neuropeptide signaling pathway • chloride transmembrane transport • chloride transport • ion transport • cellular response to amino acid stimulus • synaptic transmission, glycinergic • cellular response to ethanol • cellular response to zinc ion • excitatory postsynaptic potential • ion transmembrane transport • signal transduction • chemical synaptic transmission • regulation of membrane potential • response to amino acid • nervous system process • postsynaptic potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2742	237213
Ensembl	ENSG00000101958	ENSMUSG00000018589
UniProt	P23416	Q7TNC8
RefSeq (mRNA)	NM_001118885 NM_001118886 NM_001171942 NM_002063	NM_183427 NM_001357099 NM_001357100
RefSeq (protein)	NP_001112357 NP_001112358 NP_001165413 NP_002054	NP_906272 NP_001344028 NP_001344029
Location (UCSC)	Chr X: 14.53 – 14.73 Mb	Chr X: 165.13 – 165.33 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Glycine receptor

References

1. GRCh38: Ensembl release 89: ENSG00000101958 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018589 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GLRA2 glycine receptor, alpha 2".

Further reading

• Grenningloh G, Schmieden V, Schofield PR, et al. (1990). "Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes". EMBO J. 9 (3): 771–6. PMC 551735. PMID 2155780.
• Monani U, Burghes AH (1997). "Structure of the human alpha 2 subunit gene of the glycine receptor--use of vectorette and Alu-exon PCR". Genome Res. 6 (12): 1200–6. doi:10.1101/gr.6.12.1200. PMID 8973915.
• Cummings CJ, Dahle EJ, Zoghbi HY (1998). "Analysis of the genomic structure of the human glycine receptor alpha2 subunit gene and exclusion of this gene as a candidate for Rett syndrome". Am. J. Med. Genet. 78 (2): 176–8. doi:10.1002/(SICI)1096-8628(19980630)78:2<176::AID-AJMG16>3.0.CO;2-K. PMID 9674912.
• Feng J, Craddock N, Jones IR, et al. (2001). "Systematic screening for mutations in the glycine receptor alpha2 subunit gene (GLRA2) in patients with schizophrenia and other psychiatric diseases". Psychiatr. Genet. 11 (1): 45–8. doi:10.1097/00041444-200103000-00009. PMID 11409700.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Davies DL, Crawford DK, Trudell JR, et al. (2004). "Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism". J. Neurochem. 89 (5): 1175–85. doi:10.1111/j.1471-4159.2004.02390.x. PMID 15147510.
• Miller PS, Harvey RJ, Smart TG (2005). "Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants". Br. J. Pharmacol. 143 (1): 19–26. doi:10.1038/sj.bjp.0705875. PMC 1575261. PMID 15302677.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Miller PS, Da Silva HM, Smart TG (2006). "Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors". J. Biol. Chem. 280 (45): 37877–84. doi:10.1074/jbc.M508303200. PMID 16144831.

External links

• GLRA2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.