CHRNA2

Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene.[5][6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

CHRNA2
Identifiers
Aliases	CHRNA2, cholinergic receptor nicotinic alpha 2 subunit
External IDs	OMIM: 118502 MGI: 87886 HomoloGene: 20193 GeneCards: CHRNA2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.2 Start 27,459,756 bp[1] End 27,479,883 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D1|14 34.36 cM Start 66,135,039 bp[2] End 66,152,948 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • acetylcholine binding • acetylcholine receptor activity • ion channel activity • drug binding • extracellular ligand-gated ion channel activity • ligand-gated ion channel activity • acetylcholine-gated cation-selective channel activity • transmembrane signaling receptor activity Cellular component • integral component of membrane • acetylcholine-gated channel complex • postsynaptic membrane • membrane • cell membrane • synapse • cell junction • cell periphery • integral component of plasma membrane • neuron projection Biological process • protein heterooligomerization • response to nicotine • synaptic transmission, cholinergic • ion transport • neuromuscular synaptic transmission • signal transduction • postsynaptic potential • excitatory postsynaptic potential • ion transmembrane transport • chemical synaptic transmission • regulation of membrane potential • nervous system process • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1135	110902
Ensembl	ENSG00000120903	ENSMUSG00000022041
UniProt	Q15822	Q91X60
RefSeq (mRNA)	NM_000742 NM_001282455 NM_001347705 NM_001347706 NM_001347707 NM_001347708	NM_144803
RefSeq (protein)	NP_000733 NP_001269384 NP_001334634 NP_001334635 NP_001334636 NP_001334637	NP_659052
Location (UCSC)	Chr 8: 27.46 – 27.48 Mb	Chr 14: 66.14 – 66.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Knockout of this gene in mice potentiates nicotine-modulated behaviors.[7] Using two different genetically modified mutant mouse lines (Chrna2L9'S/L9'S and Chrna2KO), findings highlight that α2* nAChRs influence hippocampus-dependent learning and memory and CA1 synaptic plasticity in adolescent mice. [8]

See also

• Nicotinic acetylcholine receptor

References

1. GRCh38: Ensembl release 89: ENSG00000120903 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022041 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
6. "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)".
7. Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J (May 2013). "Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors". J. Neurosci. 33 (18): 7728–41. doi:10.1523/JNEUROSCI.4731-12.2013. PMC 3831006. PMID 23637165.
8. Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J (May 2017). "α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice". Learn Mem. 24 (6): 231–244. doi:10.1101/lm.045369.117. PMC 5435881. PMID 28507032.

Further reading

• Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 147: 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266.
• Wood S, Schertzer M, Yaremko ML (1995). "Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA". Somat. Cell Mol. Genet. 21 (2): 147–50. doi:10.1007/BF02255790. PMID 7570187.
• García-Colunga J, Miledi R (1995). "Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 92 (7): 2919–23. doi:10.1073/pnas.92.7.2919. PMC 42330. PMID 7708749.
• Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617.
• Chavez-Noriega LE, Crona JH, Washburn MS, et al. (1997). "Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes". J. Pharmacol. Exp. Ther. 280 (1): 346–56. PMID 8996215.
• Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand). 43 (3): 433–42. PMID 9193799.
• Sato KZ, Fujii T, Watanabe Y, et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173.
• Bertrand D, Picard F, Le Hellard S, et al. (2002). "How mutations in the nAChRs can cause ADNFLE epilepsy". Epilepsia. 43 Suppl 5: 112–22. doi:10.1046/j.1528-1157.43.s.5.16.x. PMID 12121305.
• Jin P, Fu GK, Wilson AD, et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics. 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.
• Aridon P, Marini C, Di Resta C, et al. (2006). "Increased Sensitivity of the Neuronal Nicotinic Receptor α2 Subunit Causes Familial Epilepsy with Nocturnal Wandering and Ictal Fear". Am. J. Hum. Genet. 79 (2): 342–50. doi:10.1086/506459. PMC 1559502. PMID 16826524.

External links

• CHRNA2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CHRNA2 genome location and CHRNA2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.