GRIN1

Glutamate [NMDA] receptor subunit zeta-1 is a protein that in humans is encoded by the GRIN1 gene.[5][6]

GRIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HQW, 2NR1, 3BYA, 5H8N, 5H8H, 5H8Q, 5H8F, 5I2N, 5I2K, 5KCJ, 5KDT
Identifiers
Aliases	GRIN1, GluN1, MRD8, NMDA1, NMDAR1, NR1, NMD-R1, glutamate ionotropic receptor NMDA type subunit 1, NDHMSR, NDHMSD
External IDs	OMIM: 138249 MGI: 95819 HomoloGene: 7187 GeneCards: GRIN1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 137,139,154 bp[1] End 137,168,756 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 17.14 cM Start 25,291,181 bp[2] End 25,319,187 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • receptor binding • glycine binding • calmodulin binding • GO:0001948 protein binding • cation channel activity • extracellular-glutamate-gated ion channel activity • glutamate binding • receptor activity • calcium channel activity • NMDA glutamate receptor activity • ion channel activity • ionotropic glutamate receptor activity • neurotransmitter binding • Ras guanyl-nucleotide exchange factor activity • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential • amyloid-beta binding • glutamate-gated calcium ion channel activity • signaling receptor activity • GO:0032403 macromolecular complex binding Cellular component • cytoplasm • postsynaptic membrane • membrane • synapse • NMDA selective glutamate receptor complex • neuron projection • synaptic vesicle • dendritic spine • cell surface • endoplasmic reticulum • integral component of membrane • cell membrane • GO:0097483, GO:0097481 postsynaptic density • integral component of plasma membrane • excitatory synapse • cell junction • dendrite • synaptic cleft • terminal bouton • postsynaptic density membrane • synaptic membrane • glutamatergic synapse • integral component of postsynaptic density membrane Biological process • negative regulation of neuron apoptotic process • pons maturation • synaptic transmission, glutamatergic • regulation of respiratory gaseous exchange • response to amphetamine • regulation of membrane potential • regulation of synapse assembly • learning • positive regulation of excitatory postsynaptic potential • response to ethanol • calcium ion transport • suckling behavior • prepulse inhibition • male mating behavior • regulation of long-term neuronal synaptic plasticity • adult locomotory behavior • regulation of neuron apoptotic process • ion transport • memory • regulation of axonogenesis • neuromuscular process • ionotropic glutamate receptor signaling pathway • excitatory postsynaptic potential • learning or memory • social organism behavior • regulation of neuronal synaptic plasticity • associative learning • startle response • calcium ion homeostasis • cation transport • cellular calcium ion homeostasis • cation transmembrane transport • respiratory gaseous exchange • regulation of synaptic plasticity • response to morphine • propylene metabolic process • conditioned taste aversion • cerebral cortex development • transport • nociception • olfactory learning • regulation of cell communication • visual learning • ephrin receptor signaling pathway • MAPK cascade • regulation of dendrite morphogenesis • ion transmembrane transport • long-term memory • positive regulation of apoptotic process • positive regulation of transcription from RNA polymerase II promoter • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • calcium ion transmembrane transport • regulation of ion transmembrane transport • brain development • positive regulation of calcium ion transport into cytosol • calcium-mediated signaling • protein heterotetramerization • calcium ion transmembrane import into cytosol • excitatory chemical synaptic transmission • positive regulation of reactive oxygen species biosynthetic process • protein localization to postsynaptic membrane • cellular response to amyloid-beta • response to glycine • positive regulation of cysteine-type endopeptidase activity • regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2902	14810
Ensembl	ENSG00000176884	ENSMUSG00000026959
UniProt	Q05586	P35438
RefSeq (mRNA)	NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569	NM_001177656 NM_001177657 NM_008169 NM_001372558 NM_001372559 NM_001372560 NM_001372561 NM_001372562
RefSeq (protein)	NP_000823 NP_001172019 NP_001172020 NP_015566 NP_067544	NP_001171127 NP_001171128 NP_032195 NP_001359487 NP_001359488 NP_001359489 NP_001359490 NP_001359491
Location (UCSC)	Chr 9: 137.14 – 137.17 Mb	Chr 2: 25.29 – 25.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. Although the sequence of exon 5 is identical in human and rat, the alternative exon 5 splicing in rat has yet to be demonstrated in human. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits.[6]

See also

• NMDA receptor

References

1. GRCh38: Ensembl release 89: ENSG00000176884 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026959 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (Jun 1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science. 256 (5060): 1217–21. doi:10.1126/science.256.5060.1217. PMID 1350383.
6. "Entrez Gene: GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1".

Further reading

• Lin JW, Wyszynski M, Madhavan R, et al. (1998). "Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1". J. Neurosci. 18 (6): 2017–27. doi:10.1523/JNEUROSCI.18-06-02017.1998. PMC 6792910. PMID 9482789.
• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
• Adriani W, Felici A, Sargolini F, et al. (1999). "N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes". Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. 123 (1–2): 52–9. doi:10.1007/s002210050544. PMID 9835392.
• Dingledine R, Borges K, Bowie D, Traynelis SF (1999). "The glutamate receptor ion channels". Pharmacol. Rev. 51 (1): 7–61. PMID 10049997.
• King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity". Microbes Infect. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.
• Zimmer M, Fink TM, Franke Y, et al. (1995). "Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1)". Gene. 159 (2): 219–23. doi:10.1016/0378-1119(95)00044-7. PMID 7622053.
• Karp SJ, Masu M, Eki T, et al. (1993). "Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor". J. Biol. Chem. 268 (5): 3728–33. PMID 7679115.
• Younkin DP, Tang CM, Hardy M, et al. (1993). "Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2174–8. doi:10.1073/pnas.90.6.2174. PMC 46048. PMID 7681588.
• Planells-Cases R, Sun W, Ferrer-Montiel AV, Montal M (1993). "Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain". Proc. Natl. Acad. Sci. U.S.A. 90 (11): 5057–61. doi:10.1073/pnas.90.11.5057. PMC 46653. PMID 7685113.
• Magnuson DS, Knudsen BE, Geiger JD, et al. (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237.
• Foldes RL, Rampersad V, Kamboj RK (1994). "Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits". Gene. 147 (2): 303–4. doi:10.1016/0378-1119(94)90089-2. PMID 7926821.
• Sheng M, Cummings J, Roldan LA, et al. (1994). "Changing subunit composition of heteromeric NMDA receptors during development of rat cortex". Nature. 368 (6467): 144–7. doi:10.1038/368144a0. PMID 8139656.
• Tingley WG, Roche KW, Thompson AK, Huganir RL (1993). "Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain". Nature. 364 (6432): 70–3. doi:10.1038/364070a0. PMID 8316301.
• Foldes RL, Rampersad V, Kamboj RK (1993). "Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing". Gene. 131 (2): 293–8. doi:10.1016/0378-1119(93)90309-Q. PMID 8406025.
• Collins C, Duff C, Duncan AM, et al. (1993). "Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively". Genomics. 17 (1): 237–9. doi:10.1006/geno.1993.1311. PMID 8406459.
• Lannuzel A, Lledo PM, Lamghitnia HO, et al. (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci. 7 (11): 2285–93. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID 8563977.
• Corasaniti MT, Melino G, Navarra M, et al. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID 8581564.
• Ehlers MD, Zhang S, Bernhadt JP, Huganir RL (1996). "Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit". Cell. 84 (5): 745–55. doi:10.1016/S0092-8674(00)81052-1. PMID 8625412.
• Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS. 10 (5): 463–8. doi:10.1097/00002030-199605000-00003. PMID 8724036.