HTR3E

5-hydroxytryptamine receptor 3E is a protein that in humans is encoded by the HTR3E gene.[3][4] The protein encoded by this gene is a subunit of the 5-HT3 receptor.[4]

HTR3E
Identifiers
Aliases	HTR3E, 5-HT3-E, 5-HT3E, 5-HT3c1, 5-hydroxytryptamine receptor 3E
External IDs	OMIM: 610123 HomoloGene: 50735 GeneCards: HTR3E
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 184,097,064 bp[1] End 184,106,995 bp[1]
Gene ontology Molecular function • GO:0001948 protein binding • extracellular ligand-gated ion channel activity • serotonin-gated cation-selective channel activity • ion channel activity • transmembrane signaling receptor activity Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane • neuron projection • synapse Biological process • ion transport • signal transduction • ion transmembrane transport • serotonin receptor signaling pathway • chemical synaptic transmission • regulation of membrane potential • nervous system process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	285242	n/a
Ensembl	ENSG00000186038	n/a
UniProt	A5X5Y0	n/a
RefSeq (mRNA)	NM_198314 NM_001256613 NM_001256614 NM_182589 NM_198313	n/a
RefSeq (protein)	NP_001243542 NP_001243543 NP_872395 NP_938055 NP_938056	n/a
Location (UCSC)	Chr 3: 184.1 – 184.11 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000186038 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Niesler B, Frank B, Kapeller J, Rappold GA (Jun 2003). "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E". Gene. 310: 101–11. doi:10.1016/S0378-1119(03)00503-1. PMID 12801637.
4. Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ (May 2004). "The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance". Biochem Soc Trans. 32 (Pt3): 547–52. doi:10.1042/BST0320547. PMID 15157181.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Karnovsky AM, Gotow LF, McKinley DD, et al. (2003). "A cluster of novel serotonin receptor 3-like genes on human chromosome 3". Gene. 319: 137–48. doi:10.1016/S0378-1119(03)00803-5. PMID 14597179.
• Nalivaiko E, Sgoifo A (2009). "Central 5-HT receptors in cardiovascular control during stress". Neuroscience and Biobehavioral Reviews. 33 (2): 95–106. doi:10.1016/j.neubiorev.2008.05.026. PMID 18573276.
• Kapeller J, Houghton LA, Mönnikes H, et al. (2008). "First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome". Hum. Mol. Genet. 17 (19): 2967–77. doi:10.1093/hmg/ddn195. PMID 18614545.

External links

• HTR3E+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)