Homoserine kinase

In enzymology, a homoserine kinase (EC 2.7.1.39) is an enzyme that catalyzes the chemical reaction

ATP + L-homoserine ADP + O-phospho-L-homoserine
homoserine kinase
Homoserine kinase tetramer, Methanocaldococcus jannaschii
Identifiers
EC number2.7.1.39
CAS number9026-58-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are ATP and L-homoserine, whereas its two products are ADP and O-phospho-L-homoserine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:L-homoserine O-phosphotransferase. Other names in common use include homoserine kinase (phosphorylating), and HSK. This enzyme participates in glycine, serine and threonine metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1FWK, 1FWL, 1H72, 1H73, 1H74, and 2PPQ.

gollark: Did you get He to review His valuation scheme?
gollark: no.
gollark: Anyway, the APIObid™ algorithms (which were previously ahead of the heavdrone auction handling systems) use similar predictive apiothaumaturgy to APIONET's high frequency trading work.
gollark: Just make a new magic teleporter station™ to take you 10000 blocks from spawn every time you add a new worldgen mod.
gollark: It's a forestry addon, I think.

References

    • FLAVIN M, SLAUGHTER C (1960). "Purification and properties of threonine synthetase of Neurospora". J. Biol. Chem. 235: 1103–8. PMID 13823379.
    • Watanabe Y, Konishi S, Shimura K (1957). "Biosynthesis of threonine from homoserine. VI. Homoserine kinase". J. Biochem. 44: 299–307.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.