CCL24

chemokine (C-C motif) ligand 24
Identifiers
Symbol	CCL24
Alt. symbols	SCYA24, Ckb-6, MPIF-2, eotaxin-2
NCBI gene	6369
HGNC	10623
OMIM	602495
PDB	1EIG
RefSeq	NM_002991
UniProt	O00175
Other data
Locus	Chr. 7 q11.23

Chemokine (C-C motif) ligand 24 (CCL24) also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic protein 2 (eotaxin-2) is a protein that in humans is encoded by the CCL24 gene.[1] This gene is located on human chromosome 7.[2]

Function

CCL24 is a small cytokine belonging to the CC chemokine family. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils.[3] This chemokine is also strongly chemotactic for resting T lymphocytes and slightly chemotactic for neutrophils.[1]

Clinical significance

Elevated levels of eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma.[4]

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References

Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G (April 1997). "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors". J. Exp. Med. 185 (7): 1163–72. doi:10.1084/jem.185.7.1163. PMC 2196270. PMID 9104803.
Hillier LW, Fulton RS, Fulton LA, et al. (July 2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM (November 1997). "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils". J. Leukoc. Biol. 62 (5): 667–75. PMID 9365122.
Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS (October 2009). "Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease". Allergy. 65 (3): 338–346. doi:10.1111/j.1398-9995.2009.02158.x. PMID 19796209.

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[pmid9104803-1] Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G (April 1997). "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors". J. Exp. Med. 185 (7): 1163–72. doi:10.1084/jem.185.7.1163. PMC 2196270. PMID 9104803.

[pmid12853948-2] Hillier LW, Fulton RS, Fulton LA, et al. (July 2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.

[pmid9365122-3] White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM (November 1997). "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils". J. Leukoc. Biol. 62 (5): 667–75. PMID 9365122.

[pmid19796209-4] Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS (October 2009). "Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease". Allergy. 65 (3): 338–346. doi:10.1111/j.1398-9995.2009.02158.x. PMID 19796209.