Phosphoprotein

A phosphoprotein is a protein that is posttranslationally modified by the attachment of either a single phosphate group, or a complex molecule such as 5'-phospho-DNA, through a phosphate group. The target amino acid is most often serine, threonine, or tyrosine residues (mostly in eukaryotes), or aspartic acid or histidine residues (mostly in prokaryotes).[1]

Biological function

The phosphorylation of proteins is a major regulatory mechanism in cells.[2][3]

Clinical significance

Phosphoproteins have been proposed as biomarkers for breast cancer.[4][2]

gollark: What's "MSM"?
gollark: Apparently their initial plan was just to hope for herd immunity or something, based on models they came up with for a flu pandemic, but said plans had handwaved the issue of ventilators, and the models didn't actually match COVID-19, and it took them a while to actually do something about this.
gollark: The UK doesn't seem to be doing hugely well with this whole thing to be honest.
gollark: If he *does* die it'll be very bad for morale.
gollark: That would probably be a decent approach, I suppose.

See also

References
  1. Keyword - Phosphoprotein
  2. Phosphoproteins in extracellular vesicles as candidate markers for breast cancer
  3. Cozzone AJ (1988). "Protein phosphorylation in prokaryotes". Annu. Rev. Microbiol. 42: 97–125. doi:10.1146/annurev.mi.42.100188.000525. PMID 2849375.
  4. Liquid Biopsy Could Get Boost from Phosphoproteins. 2017
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