Transforming growth factor

Transforming growth factor (sometimes referred to as tumor growth factor, or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ.

The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms. Furthermore, they do not always induce cellular transformation, and are not the only growth factors that induce cellular transformation.

Types

Function

These proteins were originally characterized by their capacity to induce oncogenic transformation in a specific cell culture system, rat kidney fibroblasts. Application of the transforming growth factors to normal rat kidney fibroblasts induces the cultured cells to proliferate and overgrow, no longer subject to the normal inhibition caused by contact between cells.

gollark: Trading Hub being, as ever, annoying: I saw a trade for basically what I want (CB Chrono Xenowyrm) but there's an extra egg there which I can't accept.
gollark: Also, 4. it's quite easy to not cause yourself with some experience, but negatively affects new players most.
gollark: 1. other people can cause sickness in your eggs.2. it's not fun; you can get a fancy egg and just lose it because you raised it wrong.3. there's a way to stop it, but it's very ineffective (ward BSA).
gollark: I think they should. Sickness is in my opinion a bit of a bad mechanic anyway.
gollark: Make sure to transfer it to an electric dragon, e.g. astrapi xeno, bolt, electric, thunder.

See also

References
  1. Matt, P; Schoenhoff, F; Habashi, J; Holm, T; Van Erp, C; Loch, D; Carlson, OD; Griswold, BF; Fu, Q; De Backer, J; Loeys, B; Huso, DL; McDonnell, NB; Van Eyk, JE; Dietz, HC (Aug 2009). "Circulating transforming growth factor-{beta} in Marfan syndrome". Circulation. 120 (6): 526–32. doi:10.1161/CIRCULATIONAHA.108.841981. PMC 2779568. PMID 19635970.
  2. Inhibiting TGF to help Marfan


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