FGF16

Fibroblast growth factor 16 is a protein which in humans is encoded by the FGF16 gene.[1][2]

fibroblast growth factor 16
Identifiers
SymbolFGF16
NCBI gene8823
HGNC3672
OMIM603724
RefSeqNM_003868
UniProtO43320
Other data
LocusChr. X q21.1

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The rat homolog is predominantly expressed in embryonic brown adipose tissue and has significant mitogenic activity, which suggests a role in proliferation of embryonic brown adipose tissue.[3]

Mutations in this gene have been found associated to cases of X-linked recessive metacarpal 4/5 fusion.[4]

gollark: I can't easily come up with a *ton* of examples of this, but stuff like generics being special-cased in for three types (because guess what, you *do* actually need them), certain basic operations returning either one or two values depending on how you interact with them, quirks of nil/closed channel operations, the standard library secretly having a `recover` mechanism and using it like exceptions a bit, multiple return values which are not first-class at all and which are used as a horrible, horrible way to do error handling, and all of go assembly, are just inconsistent and odd.
gollark: And inconsistent.
gollark: But... Google is hiring some of the smartest programmers around, can they *not* make a language which is not this, well, stupid? Dumbed-down?
gollark: It has some very nice things for the cloud-thing/CLI tool/server usecase; the runtime is pretty good and for all garbage collection's flaws manual memory management is annoying, and the standard library is pretty extensive.
gollark: I'm not entirely sure what the aim is - maybe they originally wanted to go for highly concurrent systems or something, but nowadays it seems to mostly be used in trendy cloudy things, servers, command line utilities, that sort of thing.

References
  1. Miyake A, Konishi M, Martin FH, Hernday NA, Ozaki K, Yamamoto S, Mikami T, Arakawa T, Itoh N (February 1998). "Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family". Biochemical and Biophysical Research Communications. 243 (1): 148–52. doi:10.1006/bbrc.1998.8073. PMID 9473496.
  2. Kim HS (2001). "The human FGF gene family: chromosome location and phylogenetic analysis". Cytogenetics and Cell Genetics. 93 (1–2): 131–2. doi:10.1159/000056965. PMID 11474196.
  3. "Entrez Gene: Fibroblast growth factor 16".
  4. Jamsheer A, Zemojtel T, Kolanczyk M, Stricker S, Hecht J, Krawitz P, Doelken SC, Glazar R, Socha M, Mundlos S (September 2013). "Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion". Journal of Medical Genetics. 50 (9): 579–84. doi:10.1136/jmedgenet-2013-101659. PMID 23709756.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.