BAMBI

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis), also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.[5][6]

BAMBI
Identifiers
Aliases	BAMBI, NMA, BMP and activin membrane-bound inhibitor, BMP and activin membrane bound inhibitor
External IDs	OMIM: 604444 MGI: 1915260 HomoloGene: 8215 GeneCards: BAMBI
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.1 Start 28,677,510 bp[1] End 28,682,932 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 3,507,923 bp[2] End 3,516,404 bp[2]
Gene ontology Molecular function • type II transforming growth factor beta receptor binding • GO:0005110 frizzled binding Cellular component • cytoplasm • integral component of membrane • cell membrane • membrane Biological process • positive regulation of transcription, DNA-templated • positive regulation of protein binding • negative regulation of transforming growth factor beta receptor signaling pathway • cell migration • positive regulation of epithelial to mesenchymal transition • positive regulation of cell proliferation • regulation of cell shape • positive regulation of canonical Wnt signaling pathway • transforming growth factor beta receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25805	68010
Ensembl	ENSG00000095739	ENSMUSG00000024232
UniProt	Q13145	Q9D0L6
RefSeq (mRNA)	NM_012342	NM_026505
RefSeq (protein)	NP_036474	NP_080781
Location (UCSC)	Chr 10: 28.68 – 28.68 Mb	Chr 18: 3.51 – 3.52 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000095739 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024232 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)".
6. Degen WG, Weterman MA, van Groningen JJ, Cornelissen IM, Lemmers JP, Agterbos MA, Geurts van Kessel A, Swart GW, Bloemers HP (February 1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts". Int. J. Cancer. 65 (4): 460–5. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. PMID 8621228.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lin Z, Gao C, Ning Y, et al. (2008). "The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling". J. Biol. Chem. 283 (48): 33053–8. doi:10.1074/jbc.M804039200. PMC 2662247. PMID 18838381.
• Sekiya T, Oda T, Matsuura K, Akiyama T (2004). "Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling". Biochem. Biophys. Res. Commun. 320 (3): 680–4. doi:10.1016/j.bbrc.2004.06.017. PMID 15240101.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fritzmann J, Morkel M, Besser D, et al. (2009). "A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential". Gastroenterology. 137 (1): 165–75. doi:10.1053/j.gastro.2009.03.041. PMID 19328798.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
• Khin SS, Kitazawa R, Win N, et al. (2009). "BAMBI gene is epigenetically silenced in subset of high-grade bladder cancer". Int. J. Cancer. 125 (2): 328–38. doi:10.1002/ijc.24318. PMID 19326429.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sekiya T, Adachi S, Kohu K, et al. (2004). "Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells". J. Biol. Chem. 279 (8): 6840–6. doi:10.1074/jbc.M310876200. PMID 14660579.
• Togo N, Ohwada S, Sakurai S, et al. (2008). "Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer". World J. Gastroenterol. 14 (31): 4880–8. doi:10.3748/wjg.14.4880. PMC 2739940. PMID 18756595.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Zhang Z, Henzel WJ (2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Degen WG, Weterman MA, van Groningen JJ, et al. (1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts". Int. J. Cancer. 65 (4): 460–5. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. PMID 8621228.

External links

• BAMBI+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human BAMBI genome location and BAMBI gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.