Perilipin-3

Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a protein which in humans is encoded by the M6PRBP1 gene.[5] Its gene product, as well as the gene itself, is commonly known as TIP47.

PLIN3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLIN3, M6PRBP1, PP17, TIP47, perilipin 3
External IDsOMIM: 602702 MGI: 1914155 HomoloGene: 4247 GeneCards: PLIN3
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.3Start4,838,341 bp[1]
End4,867,694 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10226

66905

Ensembl

ENSG00000105355

ENSMUSG00000024197

UniProt

O60664

Q9DBG5

RefSeq (mRNA)

NM_005817
NM_001164189
NM_001164194

NM_025836

RefSeq (protein)

NP_001157661
NP_001157666
NP_005808

NP_080112

Location (UCSC)Chr 19: 4.84 – 4.87 MbChr 17: 56.28 – 56.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.[6]

The mannose-6-phosphate receptor-binding properties of TIP47 are disputed,[7] despite the designation of M6PRBP1 as TIP47's gene symbol. TIP47 protein is most commonly described in the scientific literature as a coat protein for lipid droplets.[8]

TIP47 belongs to the peripilin protein family and shares significant homology with the other genes of this family, including perilipin and adipophilin.[9]

Interactions

M6PRBP1 has been shown to interact with both Mannose 6-phosphate receptors.[10][11]

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References
  1. GRCh38: Ensembl release 89: ENSG00000105355 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024197 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: M6PRBP1 mannose-6-phosphate receptor binding protein 1".
  6. Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR (May 2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47". Science. 292 (5520): 1373–6. Bibcode:2001Sci...292.1373C. doi:10.1126/science.1056791. PMID 11359012.
  7. Bulankina AV, Deggerich A, Wenzel D, Mutenda K, Wittmann JG, Rudolph MG, Burger KN, Höning S (May 2009). "TIP47 functions in the biogenesis of lipid droplets" (PDF). J. Cell Biol. 185 (4): 641–55. doi:10.1083/jcb.200812042. PMC 2711566. PMID 19451273.
  8. Ducharme NA, Bickel PE (March 2008). "Lipid droplets in lipogenesis and lipolysis". Endocrinology. 149 (3): 942–9. doi:10.1210/en.2007-1713. PMID 18202123.
  9. Brasaemle DL (December 2007). "Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis" (PDF). J. Lipid Res. 48 (12): 2547–59. doi:10.1194/jlr.R700014-JLR200. PMID 17878492.
  10. Díaz, E; Pfeffer S R (May 1998). "TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking". Cell. UNITED STATES. 93 (3): 433–43. doi:10.1016/S0092-8674(00)81171-X. ISSN 0092-8674. PMID 9590177.
  11. Orsel, J G; Sincock P M; Krise J P; Pfeffer S R (August 2000). "Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (16): 9047–51. Bibcode:2000PNAS...97.9047O. doi:10.1073/pnas.160251397. ISSN 0027-8424. PMC 16819. PMID 10908666.

Further reading
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