Pantetheine-phosphate adenylyltransferase

In enzymology, a pantetheine-phosphate adenylyltransferase (EC 2.7.7.3) is an enzyme that catalyzes the chemical reaction

ATP + 4'-Phosphopantetheine diphosphate + 3'-dephospho-CoA
pantetheine-phosphate adenylyltransferase
Phosphopantetheine adenylyltransferase from Thermotoga maritima. 4'-Phosphopantetheine shown as spheres. PDB 1vlh
Identifiers
EC number2.7.7.3
CAS number9026-99-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are ATP and 4'-Phosphopantetheine, whereas its two products are diphosphate and 3'-dephospho-CoA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:pantetheine-4'-phosphate adenylyltransferase. Other names in common use include dephospho-CoA pyrophosphorylase, pantetheine phosphate adenylyltransferase, dephospho-coenzyme A pyrophosphorylase, and 3'-dephospho-CoA pyrophosphorylase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1B6T, 1GN8, 1H1T, 1O6B, 1OD6, 1QJC, 1TFU, and 1VLH.

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gollark: We could use Lua. Lua is very easy to sandbox.
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gollark: > Collectivization will take place naturally as soon as state coercion is over, the workers themselveswill own their workplaces as the capitalists will no longer have any control over them. This iswhat happened during the Spanish Revolution of 1936, during which workers and farmers seized andmanaged the means of production collectively. For those capitalists who had a good attitude towardsworkers before the revolution, there was also a place - they joined the horizontal labor collectivesUm. This seems optimistic.
gollark: > "Legally anyone can start their own business. Just launch a company!”. These words oftenmentioned by the fans of capitalism are very easy to counter, because they have a huge flaw. Namely,if everyone started a company, who would work for all these companiesThis is a bizarre objection. At the somewhat extreme end, stuff *could* probably still work fine if the majority of people were contracted out for work instead of acting as employees directly.

References
    • HOAGLAND MB, NOVELLI GD (1954). "Biosynthesis of coenzyme A from phospho-pantetheine and of pantetheine from pantothenate". J. Biol. Chem. 207 (2): 767–73. PMID 13163064.
    • NOVELLI GD (1953). "Enzymatic synthesis and structure of CoA". Fed. Proc. 12 (3): 675–81. PMID 13107738.
    • Martin DP, Drueckhammer DG (1993). "Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase". Biochem. Biophys. Res. Commun. 192 (3): 1155–61. doi:10.1006/bbrc.1993.1537. PMID 8389542.
    • Geerlof A, Lewendon A, Shaw WV (1999). "Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli". J. Biol. Chem. 274 (38): 27105–11. doi:10.1074/jbc.274.38.27105. PMID 10480925.
    • Izard T, Geerlof A, Lewendon A, Barker JJ. "Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli". Acta Crystallogr. D. 55 (Pt 6): 1226–8. doi:10.1107/S0907444999004394. PMID 10329792.


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