Pantetheine-phosphate adenylyltransferase
In enzymology, a pantetheine-phosphate adenylyltransferase (EC 2.7.7.3) is an enzyme that catalyzes the chemical reaction
- ATP + 4'-Phosphopantetheine diphosphate + 3'-dephospho-CoA
| pantetheine-phosphate adenylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Phosphopantetheine adenylyltransferase from Thermotoga maritima. 4'-Phosphopantetheine shown as spheres. PDB 1vlh | |||||||||
| Identifiers | |||||||||
| EC number | 2.7.7.3 | ||||||||
| CAS number | 9026-99-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are ATP and 4'-Phosphopantetheine, whereas its two products are diphosphate and 3'-dephospho-CoA.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:pantetheine-4'-phosphate adenylyltransferase. Other names in common use include dephospho-CoA pyrophosphorylase, pantetheine phosphate adenylyltransferase, dephospho-coenzyme A pyrophosphorylase, and 3'-dephospho-CoA pyrophosphorylase. This enzyme participates in pantothenate and coa biosynthesis.
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1B6T, 1GN8, 1H1T, 1O6B, 1OD6, 1QJC, 1TFU, and 1VLH.
References
- HOAGLAND MB, NOVELLI GD (1954). "Biosynthesis of coenzyme A from phospho-pantetheine and of pantetheine from pantothenate". J. Biol. Chem. 207 (2): 767–73. PMID 13163064.
- NOVELLI GD (1953). "Enzymatic synthesis and structure of CoA". Fed. Proc. 12 (3): 675–81. PMID 13107738.
- Martin DP, Drueckhammer DG (1993). "Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase". Biochem. Biophys. Res. Commun. 192 (3): 1155–61. doi:10.1006/bbrc.1993.1537. PMID 8389542.
- Geerlof A, Lewendon A, Shaw WV (1999). "Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli". J. Biol. Chem. 274 (38): 27105–11. doi:10.1074/jbc.274.38.27105. PMID 10480925.
- Izard T, Geerlof A, Lewendon A, Barker JJ. "Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli". Acta Crystallogr. D. 55 (Pt 6): 1226–8. doi:10.1107/S0907444999004394. PMID 10329792.