Langerin

CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene.[5][6] Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.[6][7]

CD207
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3C22, 3KQG, 3P5D, 3P5E, 3P5F, 3P5G, 3P5H, 3P5I, 3P7F, 3P7G, 3P7H, 4AK8, 4N32, 4N33, 4N34, 4N35, 4N36, 4N37, 4N38
Identifiers
Aliases	CD207, CLEC4K, CD207 molecule
External IDs	OMIM: 604862 MGI: 2180021 HomoloGene: 9252 GeneCards: CD207
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 70,830,211 bp[1] End 70,835,816 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 83,671,215 bp[2] End 83,677,857 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • mannose binding • carbohydrate binding • GO:0001948 protein binding Cellular component • integral component of membrane • clathrin-coated endocytic vesicle membrane • cell membrane • endocytic vesicle • early endosome membrane • membrane Biological process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • defense response to virus • receptor-mediated endocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50489	246278
Ensembl	ENSG00000116031	ENSMUSG00000034783
UniProt	Q9UJ71	Q8VBX4
RefSeq (mRNA)	NM_015717	NM_144943
RefSeq (protein)	NP_056532	NP_659192
Location (UCSC)	Chr 2: 70.83 – 70.84 Mb	Chr 6: 83.67 – 83.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally it is known by the name C-type lectin domain family 4 member K (CD antigen CD207). It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.[5]

Clinical significance

Langerin on mucosal Langerhans cells of the human genital epithelium binds to HIV-1 and subsequently internalizes it into Birbeck granules to be degraded.[8][9]

See also

• Paul Langerhans
• Langerhans cell

References

1. GRCh38: Ensembl release 89: ENSG00000116031 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034783 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. EntrezGene 50489
6. Valladeau J; Ravel O; Dezutter-Dambuyant C; Moore K; Kleijmeer M; Liu Y; Duvert-Frances Vé; Vincent C; Schmitt D (2000). "Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, is an Endocytic Receptor that Induces the Formation of Birbeck Granules". Immunity. 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407.
7. Valladeau J; Clair-Moninot Vé; Dezutter-Dambuyant C; Pin J-J; Kissenpfennig A; Mattéi M-G; Ait-Yahia S; Bates EEM; Malissen B (2002). "Identification of Mouse Langerin/CD207 in Langerhans Cells and Some Dendritic Cells of Lymphoid Tissues". Journal of Immunology. 168 (2): 782–92. doi:10.4049/jimmunol.168.2.782. PMID 11777972.
8. De Witte L; Nabatov A; Pion M; Fluitsma D; De Jong MAWP; De Gruijl T; Piguet V; Van Kooyk Y; Geijtenbeek TBH (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells". Nature Medicine. 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373.
9. Turville S, Wilkinson J, Cameron P, Dable J, Cunningham AL (2003). "The role of dendritic cell C-type lectin receptors in HIV pathogenesis". Journal of Leukocyte Biology. 74 (5): 710–8. doi:10.1189/jlb.0503208. PMID 12960229.

Further reading

• Valladeau J, Dezutter-Dambuyant C, Saeland S (2003). "Langerin/CD207 Sheds Light on Formation of Birbeck Granules and Their Possible Function in Langerhans Cells". Immunologic Research. 28 (2): 93–107. doi:10.1385/IR:28:2:93. PMID 14610287.
• Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". The FASEB Journal. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296.
• The Sanger Centre, The Washington University Genome Sequencing Center (1998). "Toward a Complete Human Genome Sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Valladeau J; Ravel O; Dezutter-Dambuyant C; Moore K; Kleijmeer M; Liu Y; Duvert-Frances Vé; Vincent C; Schmitt D (2000). "Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, is an Endocytic Receptor that Induces the Formation of Birbeck Granules". Immunity. 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407.
• Turville SG, Cameron PU, Handley A, Lin G, Pöhlmann S, Doms RW, Cunningham AL (2002). "Diversity of receptors binding HIV on dendritic cell subsets". Nature Immunology. 3 (10): 975–83. doi:10.1038/ni841. PMID 12352970.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A (2004). "Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells". Journal of Clinical Investigation. 113 (5): 701–8. doi:10.1172/JCI19655. PMC 351318. PMID 14991068.
• Vashishta A, Fusek M, Větvička V (2005). "Possible role of procathepsin D in human cancer". Folia Microbiologica. 50 (1): 71–6. doi:10.1007/BF02931296. PMID 15954536.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Research. 14 (10b): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Verdijk P, Dijkman R, Plasmeijer EI, Mulder AA, Zoutman WH, Mieke Mommaas A, Tensen CP (2005). "A Lack of Birbeck Granules in Langerhans Cells is Associated with a Naturally Occurring Point Mutation in the Human Langerin Gene". Journal of Investigative Dermatology. 124 (4): 714–7. doi:10.1111/j.0022-202X.2005.23645.x. PMID 15816828.
• Bousarghin L (2005). "Human papillomavirus 16 virus-like particles use heparan sulfates to bind dendritic cells and colocalize with langerin in Langerhans cells". Journal of General Virology. 86 (5): 1297–1305. doi:10.1099/vir.0.80559-0. PMID 15831940.
• He B, Qiao X, Klasse PJ, Chiu A, Chadburn A, Knowles DM, Moore JP, Cerutti A (2006). "HIV-1 Envelope Triggers Polyclonal Ig Class Switch Recombination through a CD40-Independent Mechanism Involving BAFF and C-Type Lectin Receptors". Journal of Immunology. 176 (7): 3931–41. doi:10.4049/jimmunol.176.7.3931. PMID 16547227.
• Ward EM, Stambach NS, Drickamer K, Taylor ME (2006). "Polymorphisms in Human Langerin Affect Stability and Sugar Binding Activity". Journal of Biological Chemistry. 281 (22): 15450–6. doi:10.1074/jbc.M511502200. PMID 16567809.
• de Witte L; Nabatov A; Pion M; Fluitsma D; De Jong MAWP; De Gruijl T; Piguet V; Van Kooyk Y; Geijtenbeek TBH (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells". Nature Medicine. 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373.
• Kaplan DH, Li MO, Jenison MC, Shlomchik WD, Flavell RA, Shlomchik MJ (2007). "Autocrine/paracrine TGF 1 is required for the development of epidermal Langerhans cells". Journal of Experimental Medicine. 204 (11): 2545–52. doi:10.1084/jem.20071401. PMC 2118472. PMID 17938236.

External links

• CD207 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q9UJ71 (C-type lectin domain family 4 member K) at the PDBe-KB.