Sialic acid-binding Ig-like lectin 12

Sialic acid-binding Ig-like lectin 12 is a protein that in humans is encoded by the SIGLEC12 gene.[3][4][5]

SIGLEC12
Identifiers
AliasesSIGLEC12, S2V, SIGLECL1, SLG, Siglec-XII, sialic acid binding Ig like lectin 12 (gene/pseudogene), sialic acid binding Ig like lectin 12
External IDsOMIM: 606094 GeneCards: SIGLEC12
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.41Start51,491,227 bp[1]
End51,501,800 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

89858

n/a

Ensembl

ENSG00000254521

n/a

UniProt

Q96PQ1

n/a

RefSeq (mRNA)

NM_033329
NM_053003

n/a

RefSeq (protein)

NP_201586
NP_443729

n/a

Location (UCSC)Chr 19: 51.49 – 51.5 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000254521 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Foussias G, Taylor SM, Yousef GM, Tropak MB, Ordon MH, Diamandis EP (Jun 2001). "Cloning and molecular characterization of two splice variants of a new putative member of the Siglec-3-like subgroup of Siglecs". Biochem Biophys Res Commun. 284 (4): 887–99. doi:10.1006/bbrc.2001.5052. PMID 11409877.
  4. Yu Z, Lai CM, Maoui M, Banville D, Shen SH (Jun 2001). "Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs". J Biol Chem. 276 (26): 23816–24. doi:10.1074/jbc.M102394200. PMID 11328818.
  5. "Entrez Gene: SIGLEC12 sialic acid binding Ig-like lectin 12".

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.