Tick

Ticks (Ixodida) are arachnids, typically 3 to 5 mm long, part of the superorder Parasitiformes. Along with mites, they constitute the subclass Acari. Ticks are external parasites, living by feeding on the blood of mammals, birds, and sometimes reptiles and amphibians. Ticks evolved by the Cretaceous period, the most common form of fossilisation being amber immersion. Ticks are widely distributed around the world, especially in warm, humid climates.

This article is about parasitic arachnids. For the symbol, see Check mark. For other uses, see Tick (disambiguation).
Not to be confused with Tic.

Tick
Temporal range: Cenomanian to present
Ixodes ricinus, a hard tick
Scientific classification
Kingdom: Animalia
Phylum: Arthropoda
Subphylum: Chelicerata
Class: Arachnida
Subclass: Acari
Superorder: Parasitiformes
Order: Ixodida
Superfamily: Ixodoidea
Leach, 1815
Families
Diversity
18 genera, about 900 species

Almost all ticks belong to one of two major families, the Ixodidae or hard ticks, and the Argasidae or soft ticks. Adults have ovoid or pear-shaped bodies, which become engorged with blood when they feed, and eight legs. In addition to having a hard shield on their dorsal surfaces, hard ticks have a beak-like structure at the front containing the mouthparts, whereas soft ticks have their mouthparts on the underside of their bodies. Both families locate a potential host by odour or from changes in the environment.

Ticks have four stages to their lifecycle, namely egg, larva, nymph, and adult. Ixodid ticks have three hosts, taking at least a year to complete their lifecycle. Argasid ticks have up to seven nymphal stages (instars), each one requiring a blood meal. Because of their habit of ingesting blood, ticks are vectors of many diseases that affect humans and other animals.

Biology

Taxonomy and phylogeny
Fossilised tick in Dominican amber

Fossilized ticks are known from the Cretaceous onwards, most commonly in amber. They most likely originated in the Cretaceous (146 to 66 million years ago), with most of the evolution and dispersal occurring during the Tertiary (65 to 5 million years ago).[1] The oldest example is an argasid bird tick from Cretaceous New Jersey amber. The younger Baltic and Dominican ambers have also yielded examples that can be placed in living genera.[2] The tick Deinocroton draculi has been found with dinosaur feathers preserved in Cretaceous Burmese amber from 99 million years ago.[3]

Three families of ticks are described. The two large ones are the sister families of Ixodidae (hard ticks) and Argasidae (soft ticks). The third is the Nuttalliellidae, named for the bacteriologist George Nuttall. It comprises a single species, Nuttalliella namaqua,[4][5] and is the most basal lineage. It is found in southern Africa from Tanzania to Namibia and South Africa.[4][6] Ticks are closely related to the mites, within the subclass Acari.[7][8][9] rDNA analysis suggests that the Ixodidae are a clade, but that the Argasidae may be paraphyletic.[10][11]

The Ixodidae contain over 700 species of hard ticks with a scutum or hard shield, which the Argasidae lack. The Argasidae contain about 200 species; the genera accepted as of 2010 are Antricola, Argas, Nothoaspis, Ornithodoros, and Otobius.[4] They have no scutum, and the capitulum (mouth and feeding parts) is concealed beneath the body.[12] The phylogeny of the Ixodida within the Acari is shown in the cladogram, based on a 2014 maximum parsimony study of amino acid sequences of 12 mitochondrial proteins. The Argasidae appear monophyletic in this study.[13]

Acari
Parasitiformes
Ixodida (ticks)
 

Nuttalliellidae (1 species, southern Africa)

 
 
 

Ixodidae (hard ticks, ~700 species)

 
 

Argasidae (soft ticks, ~200 species)

 
 
 
 

Mesostigmata (mites, inc. Varroa)

 
 
 

Acariformes (mites)

 
 

Range and habitat

Tick species are widely distributed around the world,[14] but they tend to flourish more in countries with warm, humid climates, because they require a certain amount of moisture in the air to undergo metamorphosis, and because low temperatures inhibit their development from eggs to larvae.[15] Ticks are also widely distributed among host taxa, which include marsupial and placental mammals, birds, reptiles (snakes, iguanas, and lizards), and amphibians.[16] Ticks of domestic animals cause considerable harm to livestock by transmission of many species of pathogens, as well as causing anaemia and damaging wool and hides.[17] Some of the most debilitating species occur in tropical countries. Tropical bont ticks affect most domestic animals and occur in Africa and the Caribbean. The spinose ear tick has a worldwide distribution, the young feeding inside the ears of cattle and wild animals.[18]

In general, ticks are to be found wherever their host species occur. Migrating birds carry ticks with them on their journeys; a study of migratory birds passing through Egypt found more than half the bird species examined were carrying ticks. The species of tick often differed between the autumn and spring migrations, probably because of the seasonal periodicities of the different species.[19]

For an ecosystem to support ticks, it must satisfy two requirements; the population density of host species in the area must be high enough, and humidity must be high enough for ticks to remain hydrated.[20] Due to their role in transmitting Lyme disease, ixodid ticks, particularly the North American I. scapularis, have been studied using geographic information systems to develop predictive models for ideal tick habitats. According to these studies, certain features of a given microclimate – such as sandy soil, hardwood trees, rivers, and the presence of deer – were determined to be good predictors of dense tick populations.[21]

A habitat preferred by ticks is the interface where a lawn meets the woods,[22] or more generally, the ecotone, which is unmaintained transitional edge habitat between woodlands and open areas. Therefore, one tick management strategy is to remove leaf litter, brush, and weeds at the edge of the woods.[23] Ticks like shady, moist leaf litter with an overstory of trees or at least shrubs, and they deposit their eggs into such places in the spring, so that the larvae can emerge in the fall and crawl into low-lying vegetation. The 3 m of boundary closest to the lawn's edge are a tick migration zone, where 82% of tick nymphs in lawns are found.[24]

Anatomy and physiology
A hard-bodied tick of the family Ixodidae, the lone star tick

Ticks, like mites, are arthropods that have lost the segmentation of the abdomen (or opisthosoma) that their ancestors had, with a subsequent fusion of the abdomen with the cephalothorax (or prosoma).[25] The tagmata typical of other Chelicerata have been replaced by two new body sections, the anterior capitulum (or gnathosoma), which is retractable and contains the mouthparts, and the posterior idiosoma, which contains the legs, digestive tract, and reproductive organs.[20] The capitulum is a feeding structure with mouthparts adapted for piercing skin and sucking blood; it is only the front of the head and contains neither the brain nor the eyes.[25] Features of the capitulum include the basis capitulum, two palps, two cutting chelicerae, and hypostome. The basis capitulum supports the rest of the feeding structures. Palps have a sensory role and are composed of three sections. The hypostome is used for blood extraction and is a hollow, tube-like structure.

The ventral side of the idiosoma bears sclerites, and the gonopore is located between the fourth pair of legs. In the absence of segmentation, the positioning of the eyes, limbs, and gonopore on the idiosoma provide the only locational guidance.[25]

Most ticks are inornate, meaning they are reddish or mahogany in color and lack markings. However, some species are ornate and have distinctive white patterns on the scutum. [26]

Larval ticks hatch with six legs, acquiring the other two after a blood meal and molting into the nymph stage.[27] In the nymphal and adult stages, ticks have eight legs, each of which has seven segments and is tipped with a pair of claws. The legs are sometimes ornamented and usually bear sensory or tactile hairs.[28] In addition to being used for locomotion, the tarsus of leg I contains a unique sensory structure, Haller's organ, which can detect odors and chemicals emanating from the host, as well as sensing changes in temperature and air currents.[29][30][31] Ticks can also use Haller's organs to perceive infrared light emanating from a host.[32] When not being used for walking, the legs remain tightly folded against the body.[29][30]

In nymphs and adults of the family Ixodidae, the capitulum is prominent and projects forwards from the body, a feature not present in the Argasidae. The eyes are close to the sides of the scutum, and the large spiracles are located just behind the coxae of the fourth pair of legs.[12] The hard, protective scutellum, characteristic of this family, covers the whole dorsal surface in males, but is restricted to a small, shield-like structure behind the capitulum in females and nymphs.[33]

They differ, too, in their lifecycle: Ixodidae that attach to a host can bite painlessly and generally are unnoticed, and they remain in place until they engorge and are ready to change their skin; this process may take days or weeks. Some species drop off the host to molt in a safe place, whereas others remain on the same host and only drop off once they are ready to lay their eggs.[34]

A soft-bodied tick of the family Argasidae, beside eggs it has just laid

The body of the soft tick, family Argasidae, is pear-shaped or oval with a rounded anterior portion. The mouthparts cannot be seen from above, as they are on the ventral surface. The cuticle is leathery; often, a centrally positioned dorsal plate is seen, with ridges that project slightly above the surrounding surface, but with no decoration. A pattern of small, circular depressed areas shows where muscles are attached to the interior of the integument. The eyes are on the sides of the body, the spiracles open between legs 3 and 4, and males and females only differ in the structure of the genital pore.[35]

The Nuttalliellidae can be distinguished from both ixodid and argasid ticks by a combination of a projecting capitulum at the front and a soft, leathery skin. Other distinguish characteristics include the position of the stigmata, the lack of [[seta]ye, the strongly corrugated integument, and the form of the fenestrated plates.[36][37]

Ticks are extremely tough, hardy, and resilient animals. They can survive in a near vacuum for as long as half an hour.[38] Their slow metabolism during their dormant periods enables them to go long periods between meals.[39] During droughts, they can endure dehydration without feeding for as long as eighteen weeks, although ticks with limited energy reserves may succumb to desiccation after thirty-six weeks.[40] To keep from dehydrating, ticks hide in humid spots on the forest floor[41] or absorb water from subsaturated air by secreting hygroscopic fluid produced by the salivary glands onto the external mouthparts and then reingesting the water-enriched fluid.[42]

Ticks can withstand temperatures just above 0 °F (−18 °C) for more than two hours and can survive temperatures in the 20–29 °F (−7 – −2 °C) range for at least two weeks. Ticks have even been found in Antarctica, where they feed on penguins.[43]

Diet and feeding
A questing tick, fingers for scale

Ticks satisfy all of their nutritional requirements as ectoparasites, feeding on a diet of blood. They are obligate hematophages, needing blood to survive and move from one stage of life to another. Ticks can fast for long periods, but eventually die if unable to find a host.[44] This behavior evolved approximately 120 million years ago through adaptation to blood-feeding.[45] The behavior evolved independently in the separate tick families, with differing host-tick interactions driving the evolutionary change.[45]

Some ticks attach quickly, while others wander around looking for thinner skin, such as is found on the ears of mammals. Depending on the species and life stage, preparing to feed can take from ten minutes to two hours. On locating a suitable feeding spot, the tick grasps the host's skin and cuts into the surface.[44] It extracts blood by cutting a hole in the host's epidermis, into which it inserts its hypostome and prevents the blood from clotting by excreting an anticoagulant or platelet aggregation inhibitor.[46][47]

Ticks find their hosts by detecting animals' breath and body odors, or by sensing body heat, moisture, and vibrations.[48] They are incapable of flying or jumping, but many tick species, particularly Ixodidae, lie in wait in a position known as "questing". While questing, ticks cling to leaves and grasses by their third and fourth pairs of legs. They hold the first pair of legs outstretched, waiting to grasp and climb on to any passing host. Tick questing heights tend to be correlated with the size of the desired host; nymphs and small species tend to quest close to the ground, where they may encounter small mammalian or bird hosts; adults climb higher into the vegetation, where larger hosts may be encountered. Some species are hunters and lurk near places where hosts may rest. Upon receiving an olfactory or other stimulus, they crawl or run across the intervening surface.[48]

Other ticks, mainly the Argasidae, are nidicolous, finding hosts in their nests, burrows, or caves. They use the same stimuli as non-nidicolous species to identify hosts, with body heat and odors often being the main factors.[48] Many of them feed primarily on birds, though some Ornithodoros species, for example, feed on mammals. Both groups feed rapidly, typically biting painfully and drinking their fill within minutes. None of the species sticks to the host in the way that hard ticks do. Unlike the Ixodidae that have no fixed dwelling place except on the host, they live in sand, in crevices near animal dens or nests, or in human dwellings, where they come out nightly to attack roosting birds or emerge when they detect carbon dioxide in the breath of their hosts.[21]

Ixodidae remain in place until they are completely engorged. Their weight may increase by 200 to 600 times compared to their prefeeding weight. To accommodate this expansion, cell division takes place to facilitate enlargement of the cuticle.[49] In the Argasidae, the tick's cuticle stretches to accommodate the fluid ingested, but does not grow new cells, with the weight of the tick increasing five- to tenfold over the unfed state. The tick then drops off the host and typically remains in the nest or burrow until its host returns to provide its next meal.[35]

Tick saliva contains about 1,500 to 3,000 proteins, depending on the tick species. The proteins with anti-inflammatory properties, called evasins, help ticks to feed for eight to ten days without being perceived by the host animal. Researchers are studying these evasins with the goal of developing drugs to neutralise the chemokines that cause inflammation in myocarditis, heart attack, and stroke.[50]

Ecology

Mites and nematodes feed on ticks, which are also a minor nutritional resource for birds. More importantly, they carry diseases as the primary hosts of pathogens such as spirochaetes, and without their agency, the organisms could not reach their secondary hosts. The diseases caused may debilitate their victims, and ticks may thus be assisting in controlling animal populations and preventing overgrazing.[51]

Certain infectious diseases of humans and other animals can be transmitted by ticks, with the species of tick involved tending to be those with a wide host range. Spread of disease in this way is enhanced by the extended time during which a tick remains attached, during which time the mobile host can be carried long distances, or in the case of bird hosts, across the sea. The infective agents can be present not only in the adult tick, but also in the eggs produced plentifully by the females. Many tick species have extended their ranges as a result of the movements of people, their pets, and livestock. With increasing participation in outdoor activities such as wilderness hikes, more people and their dogs may find themselves exposed to attack.[52]

Life cycle

Both ixodid and argasid ticks have four lifecycle stages: egg, larva, nymph, and adult.[53]

Ixodidae
Main article: Ixodidae
One-host ticks

Eggs laid in the environment hatch into larvae, which immediately seek out a host in which to attach and feed. Fed larvae molt into unfed nymphs that remain on the host. After engorging on the host's blood, the nymphs molt into sexually mature adults that remain on the host in order to feed and mate. Once a female is both fed and ready to lay eggs, only then does she drop off the host in search of a suitable area to deposit her eggs. Ticks that follow this life cycle are called one-host ticks. The winter tick Dermacentor albipictus and the cattle tick Boophilus microplus are examples of one-host ticks.[54]

Two-host ticks

Newly hatched larvae attach to a host in order to obtain a blood meal. They remain on the host after developing into nymphs. After emerging from their shed larval skins, the nymphs reattach to the host and feed. Once engorged, they drop off the host and find a safe area in the natural environment in which to molt into adults. Both male and female adults seek out a host on which to attach, which may be the same body that served as host during their early development. Once attached, they feed and mate. Females ready to lay eggs drop from the host to oviposit in the environment. Ticks that complete their life cycle in this manner are called two-host ticks, like Hyalomma anatolicum excavatum.[54]

Three-host ticks

Most ixodid ticks require three hosts, and their lifecycles take at least a year to complete. Thousands of eggs are laid on the ground by an adult female tick. When the larvae emerge, they attach and feed primarily on small mammals and birds. After feeding, they detach from their hosts and molt to nymphs on the ground, which then attach and feed on larger hosts before dropping off yet again in order to molt into adults. Adults seek out a third host on which to feed and mate. Female adults engorge on blood and prepare to drop off to lay her eggs on the ground, while males feed very little and remain on the host in order to continue mating with other females.[21][54]

Argasidae
Main article: Argasidae

Argasid ticks, unlike ixodid ticks, may go through up to seven nymphal stages (instars), requiring a meal of blood each time.[55] Their lifecycles range from months to years. The adult female argasid tick can lay a few hundred to over a thousand eggs over the course of her lifetime. Larvae feed very quickly and detach to molt into nymphs. Both male and female adults feed on blood, and they mate off the host. During feeding, any excess fluid is excreted by the coxal glands, a process that is unique to argasid ticks.[21]

Relationship with humans

Tick-borne disease
Main article: Tick-borne disease
A sign in a Lithuanian forest warning of high risk of tick-borne encephalitis infection

Ticks are implicated in the transmission of a number of infections caused by pathogens such as bacteria, viruses, and protozoa. Sometimes, the tick harbours more than one type of pathogen, making diagnosis of the infection more difficult. Species of the bacterial genus Rickettsia are responsible for typhus, rickettsialpox, boutonneuse fever, African tick bite fever, Rocky Mountain spotted fever, Flinders Island spotted fever, and Queensland tick typhus (Australian tick typhus).[56] Other tick-borne diseases include Lyme disease and Q fever,[57] Colorado tick fever, Crimean Congo hemorrhagic fever, tularemia, tick-borne relapsing fever, babesiosis, ehrlichiosis, Bourbon virus, and tick-borne meningoencephalitis, as well as bovine anaplasmosis and probably the Heartland virus.[58]

Some species, notably the Australian paralysis tick, are also intrinsically venomous and can cause tick paralysis. Eggs can become infected with pathogens inside a female tick's ovaries, in which case the larval ticks are infectious immediately at hatching, before feeding on their first host.[55] Tropical bont ticks transmit the rickettsial disease heartwater, which can be particularly devastating in cattle.[18] The ticks carried by migratory birds may act as reservoirs and vectors of infectious diseases. Over 20 strains of pathogenic viruses were found in the autumn in the Egyptian migratory bird study.[19]

Not all ticks in an infective area are infected with pathogens, and both attachment of the tick and a long feeding session seem to be necessary for transmission of these diseases to take place.[52] Thus, tick bites often do not lead to infection, especially if the ticks are removed within 36 hours.[59] While adult ticks can be removed with fine-tipped tweezers or proprietary tick removal tools, disinfecting the wound,[60][61][62] there is growing consensus that ticks should be left in situ and frozen with either a custom spray or medical wart remover and left to fall out.[63][64] Professor Sheryl van Nunen, whose research in 2007 identified tick-induced mammalian meat allergy, has famously said "tweezers are tick squeezers"[65][64], referring to the tick toxins squeezed into people by attempting to remove ticks with tweezers. Ticks can be disposed of by flushing them down the toilet, placing them in a container of soapy water or alcohol, or sticking them to tape that can then be folded over and thrown away.[27][62]

Bifenthrin and permethrin, both pyrethroids, are sometimes used as tick-control measures, although a downside is that they are carcinogenic and can attack the nervous systems of other species besides ticks. Those who walk through tick-infested areas can make it harder for ticks to latch onto them by tucking their slacks into boots made of smooth rubber, which ticks have more trouble climbing than other material.[66][67]

Research since 2008 has documented red-meat allergies (known as mammalian meat allergy and Alpha-gal allergy) in the U.S. due to lone star tick bites. The range of the problem has been expanding with the range of the tick. Other species of ticks are known for being responsible for meat allergies in other countries[68], including Sweden, Germany, and especially Australia, where research by Sheryl van Nunen discovered the existence of the allergy there.

Many tick-transmitted viruses, such as Crimean-Congo hemorrhagic fever virus, Kyasanur Forest disease virus, Alkhumra hemorrhagic fever virus, and Omsk hemorrhagic fever virus, are classified as dangerous enough to require biosafety level 4 precautions in laboratory environments. This includes five levels of containment, viz., storage vials within humidified desiccators, within environmental chambers, within a tick suite, within a BSL4 laboratory. Precautions such as glove boxes, sticky pads, Vaseline barriers, safety suits, gloves, sticky tape, silicone vacuum grease, sticky trap paste, and micro mesh are used to safely contain ticks and prevent them from escaping.[69]

Population control measures
Researcher collecting ticks using the "tick dragging" method

With the possible exception of widespread DDT use in the Soviet Union, attempts to limit the population or distribution of disease-causing ticks have been quite unsuccessful.[70] The parasitoid chalcid wasp Ixodiphagus hookeri has been investigated for its potential to control tick populations. It lays its eggs into ticks;[71][lower-alpha 1] the hatching wasps kill their hosts.[72]

Predators and competitors of tick hosts can indirectly reduce the density of infected nymphs, thereby lowering tick-borne disease risk by lowering the density and/or tick burden of reservoir-competent hosts. A study in the Netherlands found that the number of larval ticks on bank voles and wood mice was lower at sites with significant red fox (Vulpes vulpes) and stone marten (Martes foina) activity.[73]

This supports the results of a study from the northeastern United States, in which the incidence of Lyme borreliosis was negatively correlated with the density of red fox, possibly because foxes decrease the density of white-footed mice (Peromyscus leucopus), the most important reservoir-competent host for Borrelia burgdorferi.[73][74]

Another natural form of control for ticks is the guineafowl, a bird species that consumes mass quantities of ticks.[75] Opossums also are net destroyers of ticks, killing around ninety percent of the ticks that attempt to feed on them.[76] More generally, high animal diversity has a strongly protective effect against tick-borne disease.[24]

Topical tick medicines may be toxic to animals and humans. The synthetic pyrethroid insecticide phenothrin in combination with the hormone analogue methoprene was a popular topical flea and tick therapy for felines. Phenothrin kills adult ticks, while methoprene kills eggs. However, some products have been withdrawn, while others are known to cause adverse reactions.[77]

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gollark: But he's somewhat bad? We have examples?
gollark: <https://cdn.discordapp.com/attachments/738758410446569563/739587538905333810/unknown.png>
gollark: We have a picture of when he has been annoying.
gollark: <@319753218592866315> transfer votes to gibson.

See also

Notes
  1. Micrographs of the wasp laying eggs into a tick, and the hole by which the young wasps emerge from the tick's dead body, are available in Plantard et al 2012.[71]

References
  1. de la Fuente (2003)
  2. Dunlop, Jason A.; et al. (2016). "Microtomography of the Baltic amber tick Ixodes succineus reveals affinities with the modern Asian disease vector Ixodes ovatus". BMC Evolutionary Biology. 16 (1): 203. doi:10.1186/s12862-016-0777-y. PMC 5057450. PMID 27724841.
  3. Peñalver, Enrique; Arillo, Antonio; Delclòs, Xavier; Peris, David; Grimaldi, David A.; Anderson, Scott R.; Nascimbene, Paul C.; Pérez-de la Fuente, Ricardo (2017). "Ticks parasitised feathered dinosaurs as revealed by Cretaceous amber assemblages". Nature Communications. 8 (1): 1924. Bibcode:2017NatCo...8.1924P. doi:10.1038/s41467-017-01550-z. PMC 5727220. PMID 29233973.
  4. Guglielmone et al. (2010)
  5. Goddard (2008): p. 80
  6. Keirans et al. (1976)
  7. Barker, S. C.; Murrell, A. (2004). "Systematics and evolution of ticks with a list of valid genus and species names". Parasitology. 129 (S1): S15–S36. doi:10.1017/S0031182004005207. PMID 15938503.
  8. Klompen, J. S.; Black, W. C.; Keirans, J. E.; Oliver, J. H. (1996). "Evolution of ticks". Annual Review of Entomology. 41: 141–61. doi:10.1146/annurev.ento.41.1.141. PMID 8546444.
  9. Anderson, John F. (2002). "The natural history of ticks". Medical Clinics of North America. 86 (2): 205–218. doi:10.1016/s0025-7125(03)00083-x. PMID 11982298.
  10. Crampton, A.; McKay, I.; Barker, S. C. (May 1996). "Phylogeny of ticks (Ixodida) inferred from nuclear ribosomal DNA". International Journal for Parasitology. 26 (5): 511–517. doi:10.1016/0020-7519(96)89379-9. PMID 8818731.
  11. Black, William C., IV; Piesman, Joseph (October 1994). "Phylogeny of hard- and soft-tick taxa (Acari: Ixodida) based on mitochondrial 16S rDNA sequences". PNAS. 91 (21): 10034–10038. Bibcode:1994PNAS...9110034B. doi:10.1073/pnas.91.21.10034. PMC 44952. PMID 7937832.
  12. Molyneux (1993) p. 6
  13. Gu, X. B.; et al. (2014). "The complete mitochondrial genome of the scab mite Psoroptes cuniculi (Arthropoda: Arachnida) provides insights into Acari phylogeny". Parasites & Vectors. 7: 340. doi:10.1186/1756-3305-7-340. PMC 4223567. PMID 25052180.
  14. Magnarelli (2009)
  15. Nuttall (1905)
  16. Dantas-Torres, Filipe; Oliveira-Filho, Edmilson F.; Soares, Fábio Ângelo M.; Souza, Bruno O. F.; Valença, Raul Baltazar P.; Sá, Fabrício B. (2008). "Ticks Infesting Amphibians and Reptiles in Pernambuco, Northeastern Brazil". Revista Brasileira de Parasitologia Veterinária. 17 (4): 218–221. doi:10.1590/S1984-29612008000400009. PMID 19265581.
  17. "Ticks of Livestock". Ectoparasites of Livestock. Butox. Retrieved 14 January 2017.
  18. "Ticks". Livestock Veterinary Entomology. Texas A&M AgriLife. Retrieved 14 January 2017.
  19. Hoogstraal, Harry; Kaiser, Makram N.; Traylor, Melvin A.; Guindy, Ezzat; Gaber, Sobhy (1963). "Ticks (Ixodidae) on birds migrating from Europe and Asia to Africa, 1959–61". Bulletin of the World Health Organization. 28 (2): 235–262. PMC 2554471. PMID 13961632.
  20. Wall & Shearer (2001): p. 55
  21. Allan (2001)
  22. Beans, Carolyn (20 July 2016). "Taking The Battle Against Lyme Disease Ticks To The Backyard". NPR.
  23. "Integrated Tick Management" (PDF). Connecticut Agricultural Experimental Station.
  24. Tucker, Becca (11 May 2018). "The tick-resistant yard". Dirt Magazine.
  25. Ruppert, Edward E.; Fox, Richard S.; Barnes, Robert D. (2004). Invertebrate Zoology, 7th edition. Cengage Learning. pp. 590–595. ISBN 978-81-315-0104-7.
  26. Sirois, Margi (2015). Laboratory Procedures for Veterinary Technicians. St. Louis, MO: Elsevier. ISBN 978-0-323-16930-1.
  27. "Common Ticks". Illinois Department of Public Health. Retrieved 11 April 2014.
  28. "Soft ticks". CVBD: Companion Vector-Borne Diseases. Retrieved 6 December 2016.
  29. Sonenshine (2005): p. 14
  30. Nicholson et al. (2009): p. 486
  31. For Haller's organ, see also: Mehlhorn (2008): p. 582.
  32. Mitchell, R. D., III; Zhu, J.; Carr, A. L.; Dhammi, A.; Cave, G.; Sonenshine, D. E.; Roe, R. M. (2017). "Infrared light detection by the haller's organ of adult American dog ticks, Dermacentor variabilis (Ixodida: Ixodidae)". Ticks and Tick-borne Diseases. 8 (5): 764–771. doi:10.1016/j.ttbdis.2017.06.001. PMC 5588665. PMID 28647127.
  33. Walker, Jane B.; Keirans, James E.; Horak, Ivan G. (2005). The Genus Rhipicephalus (Acari, Ixodidae): A Guide to the Brown Ticks of the World. Cambridge University Press. p. 39. ISBN 978-1-316-58374-6.
  34. Salman, Mowafak Dauod; Tarrés-Call, Jordi; Estrada-Peña, Agustín (2013). Ticks and Tick-borne Diseases: Geographical Distribution and Control Strategies in the Euro-Asia Region. CABI. pp. 6–12. ISBN 978-1-84593-853-6.
  35. "Soft ticks". CVBD: Companion Vector-Borne Diseases. Retrieved 6 December 2016.
  36. Roshdy et al. (1983)
  37. Brouwers, Lucas (30 August 2011). "Long Lost Relative of Ticks Pops Up Again". Scientific American. Retrieved 4 December 2016.
  38. Yong, Ed (15 March 2012). "Stuffed in a vacuum and bombarded by electrons, a tick waves hello". Discover.
  39. Miller, Michael (20 November 2018). "UC study: Hungry ticks work harder to find you". UC Cincinnati.
  40. Rosendale AJ (August 2017). "Dehydration and starvation yield energetic consequences that affect survival of the American dog tick". J Insect Physiol. 101: 39–46. doi:10.1016/j.jinsphys.2017.06.012. PMID 28648807.
  41. Zimmer, Carl (30 April 2013). "The Rise of the Tick". Outside.
  42. Gray, Jeremy S.; Kahl, Olaf; Lane, Robert S.; Levin, Michael L.; Tsao, Jean I. (July 2016). "Diapause in ticks of the medically important Ixodes ricinus species complex". Ticks and Tick-borne Diseases. 7 (5): 992–1003. doi:10.1016/j.ttbdis.2016.05.006. PMC 5659180. PMID 27263092.CS1 maint: multiple names: authors list (link)
  43. "Ticks are even tougher and nastier than you thought". Science Daily. 25 September 2017.
  44. "Life cycle of Hard Ticks that Spread Disease". Centers for Disease Control and Prevention. Retrieved 22 June 2013.
  45. Klompen, Hans; Grimaldi, David (2001). "First Mesozoic Record of a Parasitiform Mite: a Larval Argasid Tick in Cretaceous Amber (Acari: Ixodida: Argasidae)" (PDF). Annals of the Entomological Society of America. 94 (1): 10–15. doi:10.1603/0013-8746(2001)094[0010:FMROAP]2.0.CO;2.
  46. Goddard (2008): p. 82
  47. Mans, Ben J.; Louw, Abraham I.; Neitz, Albert W. H. (2002). "Evolution of Hematophagy in Ticks: Common Origins for Blood Coagulation and Platelet Aggregation Inhibitors from Soft Ticks of the Genus Ornithodoros". Molecular Biology and Evolution. 19 (10): 1695–1705. doi:10.1093/oxfordjournals.molbev.a003992. PMID 12270896.
  48. "Host seeking". CVBD: Companion Vector-Borne Diseases. Retrieved 8 December 2016.
  49. "Hard ticks". CVBD: Companion Vector-Borne Diseases. Retrieved 6 December 2016.
  50. University of Oxford (27 June 2017). "From bug to drug—tick saliva could be key to treating heart disease". Phys.org.
  51. Ray, C. Claiborne (28 May 2012). "The mighty tick". New York Times. Retrieved 15 December 2016.
  52. "Disease transmission". CVBD: Companion Vector-Borne Diseases. Retrieved 9 December 2016.
  53. Dennis & Piesman (2005): p. 5
  54. Sonenshine, D. (1991) Biology of Ticks. Oxford University Press, New York.
  55. Aeschlimann & Freyvogel, 1995: p. 182
  56. Unsworth, N. B.; Stenos, J.; Graves, S. R.; et al. (2007). "Flinders Island spotted fever rickettsioses caused by 'marmionii' strain of Rickettsia honei, Eastern Australia". Emerging Infectious Diseases. 13 (4): 566–73. doi:10.3201/eid1304.050087. PMC 2725950. PMID 17553271.
  57. "Q fever". Centers for Disease Control. Retrieved 7 November 2010.
  58. "Heartland virus". 8 November 2018.
  59. Feldman, Getty; Feldman, Lauree; Macnair, Patricia (6 March 2014). "All about ticks: why it's so important to remove a tick". Netdoctor. Retrieved 8 December 2016.
  60. "Correct tick removal". 26 October 2015. Retrieved 27 January 2018.
  61. "Tick removal". Lyme Disease Action. Retrieved 24 October 2014.
  62. "Tick removal". Centers for Disease Control and Prevention. Retrieved 24 October 2014.
  63. "Catalyst: Tick allergy – ABC TV Science". www.abc.net.au. 17 February 2015. Retrieved 10 December 2015.
  64. Salleh, Anna (1 January 2020). "Tweeze vs freeze: Here's the lowdown on how to get rid of a tick". ABC News. Retrieved 15 February 2020.
  65. "TIARA - Tick Induced Allergies Research and Awareness". TIARA - Tick Induced Allergies Research and Awareness. Retrieved 15 February 2020.
  66. Atwell, Tom (3 January 2016). "Pesticides may get rid of ticks, but at what cost?". Press Herald.
  67. Figura, David (4 June 2014). "Outdoors experts: Keep ticks off by spraying repellent on your clothes". Syracuse.com.
  68. Aubrey, Allison (25 June 2018). "Red Meat Allergies Caused By Tick Bites Are On The Rise". NPR. Retrieved 26 June 2018.
  69. Thangamani, S.; Bente, D. (July 2015). "Establishing protocols for tick containment at Biosafety Level 4". Pathogens and Disease. 71 (2): 282–5. doi:10.1111/2049-632X.12187. PMC 4107070. PMID 24838773.
  70. Dennis & Piesman, 2005: p. 3
  71. Plantard, O.; et al. (2012). "Detection of Wolbachia in the tick Ixodes ricinus is due to the presence of the hymenoptera endoparasitoid Ixodiphagus hookeri". PLOS ONE. 7 (1): e30692. Bibcode:2012PLoSO...730692P. doi:10.1371/journal.pone.0030692. PMC 3266912. PMID 22292021.
  72. Tijsse-Klasen, Ellen; et al. (2011). "Parasites of vectors – Ixodiphagus hookeri and its Wolbachia symbionts in ticks in the Netherlands". Parasites & Vectors. 4: 228. doi:10.1186/1756-3305-4-228. PMC 3248373. PMID 22152674.
  73. Hofmeester, T. R.; Jansen, P. A.; Wijnen, H. J.; Copian, E. C.; Fonville, M.; Prins, H. H. T.; Sprong, H.; van Wieren, S. E. (2017). "Cascading effects of predator activity on tick-borne disease risk". Proceedings of the Royal Society B: Biological Sciences. 284 (1859): 20170453. doi:10.1098/rspb.2017.0453. PMC 5543215. PMID 28724731. Material was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.
  74. Levi, T; Kilpatrick, AM; Mangel, M; Wilmers, CC (2012). "Deer, predators, and the emergence of Lyme disease". PNAS. 109 (27): 10942–10947. Bibcode:2012PNAS..10910942L. doi:10.1073/pnas.1204536109. PMC 3390851. PMID 22711825.
  75. Duffy et al. (1992)
  76. Main, Dalton (13 June 2018). "'Destroyers of ticks': How opossums help fight ticks and Lyme Disease". Boston 25 News.
  77. "Hartz flea and tick drops for cats and kittens to be phased out". Environmental Protection Agency. Archived from the original on 11 January 2010. Retrieved 16 September 2011.

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