CDS1 (gene)

Function

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.[8][9] and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (this gene) and a second (CDS2) to 20p13.[7]

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References
  1. GRCh38: Ensembl release 89: ENSG00000163624 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029330 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM (Jan 1999). "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics. 54 (1): 140–144. doi:10.1006/geno.1998.5547. PMID 9806839.
  6. Weeks R, Dowhan W, Shen H, Balantac N, Meengs B, Nudelman E, Leung DW (Apr 1997). "Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA". DNA Cell Biol. 16 (3): 281–289. doi:10.1089/dna.1997.16.281. PMID 9115637.
  7. "Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1".
  8. M. Nowicki & M. Frentzen (2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161–2165. doi:10.1016/j.febslet.2005.03.007. PMID 15811335.
  9. M. Nowicki (2006). "Characterization of the Cardiolipin Synthase from Arabidopsis thaliana". Ph.D. thesis, RWTH-Aachen University. Archived from the original on 2011-10-05. Retrieved 2011-07-11.

Further reading


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