SPHK2

Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.[5]

SPHK2
Identifiers
AliasesSPHK2, SK 2, SK-2, SPK 2, SPK-2, sphingosine kinase 2
External IDsOMIM: 607092 MGI: 1861380 HomoloGene: 32456 GeneCards: SPHK2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.33Start48,619,291 bp[1]
End48,630,717 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

56848

56632

Ensembl

ENSG00000063176

ENSMUSG00000057342

UniProt

Q9NRA0

Q9JIA7

RefSeq (mRNA)

NM_001204158
NM_001204159
NM_001204160
NM_001243876
NM_020126

NM_001172561
NM_020011
NM_203280

RefSeq (protein)

NP_001191087
NP_001191088
NP_001191089
NP_001230805
NP_064511

NP_001166032
NP_064395
NP_975009

Location (UCSC)Chr 19: 48.62 – 48.63 MbChr 7: 45.71 – 45.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].[5]

Inhibitors

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References

  1. GRCh38: Ensembl release 89: ENSG00000063176 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000057342 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Sphingosine kinase 2". Retrieved 2011-12-22.

Further reading


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