LILRA4

Leukocyte immunoglobulin-like receptor subfamily A member 4 is a protein that in humans is encoded by the LILRA4 gene.[3][4]

LILRA4
Identifiers
Aliases	LILRA4, CD85g, ILT7, leukocyte immunoglobulin like receptor A4
External IDs	OMIM: 607517 HomoloGene: 69118 GeneCards: LILRA4
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,333,185 bp[1] End 54,339,162 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • receptor binding • coreceptor activity Cellular component • membrane • integral component of membrane • integral component of plasma membrane • Fc-epsilon receptor I complex • cell membrane Biological process • immune system process • negative regulation of interferon-alpha production • negative regulation of tumor necrosis factor production • negative regulation of toll-like receptor 7 signaling pathway • negative regulation of toll-like receptor 9 signaling pathway • Fc-epsilon receptor signaling pathway • innate immune system Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23547	n/a
Ensembl	ENSG00000277092 ENSG00000276798 ENSG00000274185 ENSG00000239961	n/a
UniProt	P59901	n/a
RefSeq (mRNA)	NM_012276	n/a
RefSeq (protein)	NP_036408	n/a
Location (UCSC)	Chr 19: 54.33 – 54.34 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte immunoglobulin-like receptor gene cluster (LRC) at chromosomal region 19q13.4.[4]

References

1. ENSG00000276798, ENSG00000274185, ENSG00000239961 GRCh38: Ensembl release 89: ENSG00000277092, ENSG00000276798, ENSG00000274185, ENSG00000239961 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842.
4. "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4".

Further reading

• Cho M, Ishida K, Chen J, et al. (2008). "SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production". Int. Immunol. 20 (1): 155–64. doi:10.1093/intimm/dxm127. PMID 18048391.
• Sellick GS, Wade R, Richards S, et al. (2008). "Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis". Blood. 111 (3): 1625–33. doi:10.1182/blood-2007-08-110130. PMID 18006695.
• Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
• Cao W, Rosen DB, Ito T, et al. (2006). "Plasmacytoid dendritic cell–specific receptor ILT7–FcɛRIγ inhibits Toll-like receptor–induced interferon production". J. Exp. Med. 203 (6): 1399–405. doi:10.1084/jem.20052454. PMC 2118323. PMID 16735691.
• Ju XS, Hacker C, Scherer B, et al. (2004). "Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation". Gene. 331: 159–64. doi:10.1016/j.gene.2004.02.018. PMID 15094202.
• Tedla N, Bandeira-Melo C, Tassinari P, et al. (2003). "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1174–9. doi:10.1073/pnas.0337567100. PMC 298746. PMID 12529506.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rissoan MC, Duhen T, Bridon JM, et al. (2002). "Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells". Blood. 100 (9): 3295–303. doi:10.1182/blood-2002-02-0638. PMID 12384430.
• Young NT, Canavez F, Uhrberg M, et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530.